ArticleMolecular biology of the cell2010
Overlapping roles of Drosophila Drak and Rok kinases in epithelial tissue morphogenesis.
Article in Molecular biology of the cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 22 citations in OpenAlex.
- Drak is a potential binding partner of Drosophila Filamin.Biology open · 2026Article
- STK17A (DRAK1) at the crossroads of apoptosis, immunity, and cancer: Emerging roles and therapeutic opportunities.Theranostics · 2026Review
- DRAK2 regulates myosin light chain phosphorylation in T cells.Journal of cell science · 2024Article
- Article
- Predictive significance of STK17A in patients with gastric cancer and association with gastric cancer cell proliferation and migration.Oncology reports · 2021Article
- Protein Kinase D Is Dispensable for Development and Survival ofG3 (Bethesda, Md.) · 2019Article
- Drak/STK17A Drives Neoplastic Glial Proliferation through Modulation of MRLC Signaling.Cancer research · 2019Article
- Genetic interactions betweenHereditas · 2019Article
- Drosophila melanogaster as a Model System for Human Glioblastomas.Advances in experimental medicine and biology · 2019Review
- Yorkie Functions at the Cell Cortex to Promote Myosin Activation in a Non-transcriptional Manner.Developmental cell · 2018Article
- The transcription factor Dysfusion promotes fold and joint morphogenesis through regulation of Rho1.PLoS genetics · 2018Article
- Drak Is Required for Actomyosin Organization During Drosophila Cellularization.G3 (Bethesda, Md.) · 2016Article
- Abnormal Localization of STK17A in Bile Canaliculi in Liver Allografts: An Early Sign of Chronic Rejection.PloS one · 2015Article
- A novel DRAK inhibitor, SC82510, promotes axon branching of adult sensory neurons in vitro.Neurochemical research · 2014Article
- Insights into the functions of the death associated protein kinases from C. elegans and other invertebrates.Apoptosis : an international journal on programmed cell death · 2014Review
- Serine/threonine kinase 17A is a novel candidate for therapeutic targeting in glioblastoma.PloS one · 2013Article
- Atonal and EGFR signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.Development (Cambridge, England) · 2012Article
- Par-1 controls myosin-II activity through myosin phosphatase to regulate border cell migration.Current biology : CB · 2012Article
- Identification, expression and target gene analyses of Micrornas in Spodoptera litura.PloS one · 2012Article
- The ultrastructure of book lung development in the bark scorpion Centruroides gracilis (Scorpiones: Buthidae).Frontiers in zoology · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Dynamic regulation of cytoskeletal contractility through phosphorylation of the nonmuscle Myosin-II regulatory light chain (MRLC) provides an essential source of tension for shaping epithelial tissues. Rho GTPase and its effector kinase ROCK have been implicated in regulating MRLC phosphorylation in vivo, but evidence suggests that other mechanisms must be involved. Here, we report the identification of a single Drosophila homologue of the Death-associated protein kinase (DAPK) family, called Drak, as a regulator of MRLC phosphorylation. Based on analysis of null mutants, we find that Drak broadly promotes proper morphogenesis of epithelial tissues during development. Drak activity is largely redundant with that of the Drosophila ROCK orthologue, Rok, such that it is essential only when Rok levels are reduced. We demonstrate that these two kinases synergistically promote phosphorylation of Spaghetti squash (Sqh), the Drosophila MRLC orthologue, in vivo. The lethality of drak/rok mutants can be rescued by restoring Sqh activity, indicating that Sqh is the critical common effector of these two kinases. These results provide the first evidence that DAPK family kinases regulate actin dynamics in vivo and identify Drak as a novel component of the signaling networks that shape epithelial tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.