ArticleThe Journal of biological chemistry2010
Beta,beta-carotene decreases peroxisome proliferator receptor gamma activity and reduces lipid storage capacity of adipocytes in a beta,beta-carotene oxygenase 1-dependent manner.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
73 citing papers in PubMed, 148 citations in OpenAlex.
- Effects of Mixed Carotenoids on Adipokines and Abdominal Adiposity in Children: A Pilot Study.The Journal of clinical endocrinology and metabolism · 2017Trial
- Oral Toxicity Profile of a Novel Silk Lutein Extract and Assessment of Its Cardiovascular Benefits in Rodents.International journal of molecular sciences · 2026Article
- Effects of Dietary Vitamin A Concentration and Stress on Astaxanthin Utilization in Atlantic Salmon (Aquaculture nutrition · 2026Article
- Potential of siphonaxanthin, a green algal carotenoid, to prevent obesity and related diseases.Journal of natural medicines · 2025Review
- Histopathological Characteristics and Multi-Omics Analysis of Ocular Pigmentation Defects in AlbinoCells · 2025Article
- Exploring the Potential of Carotenoids in Obesity Management: A Comprehensive Overview.Recent advances in food, nutrition & agriculture · 2025Review
- Natural bioactive compounds and their mechanisms of action in the management of obesity: a narrative review.Frontiers in nutrition · 2025Review
- Overview of oxidative stress and inflammation in diabetes.Journal of diabetes · 2024Review
- Review
- Article
- β-carotene accelerates the resolution of atherosclerosis in mice.bioRxiv : the preprint server for biology · 2024Article
- Association of dietary and circulating antioxidant vitamins with metabolic syndrome: an observational and Mendelian randomization study.Frontiers in endocrinology · 2024Observational
- Associations of serum carotenoids with visceral adiposity index and lipid accumulation product: a cross-sectional study based on NHANES 2001-2006.Lipids in health and disease · 2023Article
- Macauba (Nutrients · 2023Article
- Dietary Level of the Omega-3 Fatty Acids EPA and DHA Influence the Flesh Pigmentation in Atlantic Salmon.Aquaculture nutrition · 2023Article
- Effects of dietary vitamins on obesity-related metabolic parameters.Journal of nutritional science · 2023Review
- Vitamin A: A Key Inhibitor of Adipocyte Differentiation.PPAR research · 2023Review
- Review
- Article
- β-Carotene from the AlgaMarine drugs · 2022Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Increasing evidence has been provided for a connection between retinoid metabolism and the activity of peroxisome proliferator receptors (Ppars) in the control of body fat reserves. Two different precursors for retinoids exist in the diet as preformed vitamin A (all-trans-retinol) and provitamin A (beta,beta-carotene). For retinoid production, beta,beta-carotene is converted to retinaldehyde by beta,beta-carotene monooxygenase 1 (Bcmo1). Previous analysis showed that Bcmo1 knock-out mice develop dyslipidemia and are more susceptible to diet-induced obesity. However, the role of Bcmo1 for adipocyte retinoid metabolism has yet not been well defined. Here, we showed that Bcmo1 mRNA and protein expression are induced during adipogenesis in NIH 3T3-L1 cells. In mature adipocytes, beta,beta-carotene but not all-trans-retinol was metabolized to retinoic acid (RA). RA decreased the expression of Ppar gamma and CCAAT/enhancer-binding protein alpha, key lipogenic transcription factors, and reduced the lipid content of mature adipocytes. This process was inhibited by the retinoic acid receptor antagonist LE450, showing that it involves canonical retinoid signaling. Accordingly, gavage of beta,beta-carotene but not all-trans-retinol induced retinoid signaling and decreased Ppar gamma expression in white adipose tissue of vitamin A-deficient mice. Our study identifies beta,beta-carotene as a critical physiological precursor for RA production in adipocytes and implicates provitamin A as a dietary regulator of body fat reserves.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.