Evidence map›Paper›PMID 20573799›Full record

Trial reportThe American journal of clinical nutrition2010

Caffeine consumption and incident atrial fibrillation in women.

David Conen, Stephanie E Chiuve, Brendan M Everett, Shumin M Zhang, Julie E Buring, Christine M Albert

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 38 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 8 pooled it
5.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00000479 phase3completednot on this map

Women's Health Study of Low-dose Aspirin and Vitamin E in Apparently Healthy Women

TypeinterventionalSponsorBrigham and Women's HospitalRan1992 to 2005Enrolled39,876ConditionsCardiovascular Diseases, Cerebrovascular Disorders, Coronary Disease, Heart DiseasesArmsAspirin, Vitamin E, Placebo
NCT05464940 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Impact of Intravenous Caffeine on Atrial Electrical Properties and Potential Arrythmia Induction in Patients With Paroxysmal Atrial Fibrillation: The COFFEE-AF Trial

TypeinterventionalSponsorKansas City Heart Rhythm Research FoundationRan2025 to 2026Enrolled100ConditionsAtrial FibrillationArmsIntravenous caffeine, Masked Placebo
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 8 syntheses or guidelines pooled it, 103 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Guideline
  4. Dietary interventions in the management of atrial fibrillation.Frontiers in cardiovascular medicine · 2024
    Pooled it
  5. Pooled it
  6. European Heart Rhythm Association (EHRA)/European Association of Cardiovascular Prevention and Rehabilitation (EACPR) position paper on how to prevent atrial fibrillation endorsed by the Heart Rhythm Society (HRS) and Asia Pacific Heart Rhythm Society (APHRS).Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2017
    Guideline
  7. Guideline
  8. Pooled it
  9. Article
  10. Review
  11. Observational
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

David ConenCenter for Arrhythmia Prevention, Department of Medicine, Brigham and Womenrsquos Hospital, Harvard Medical School, Boston, MA, USA. conend@uhbs.ch
Stephanie E Chiuve
Brendan M Everett
Shumin M Zhang
Julie E Buring
Christine M Albert
Brigham and Women's Hospital · US

Funding

Women's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2M
Women's Health Study: Continued Follow-UpR01HL080467 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E. · 2005 to 2010
$4.5M
TRIAL OF VITAMIN E, BETA-CAROTENE &ASPRIN IN WOMENR01HL043851 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1991 to 2000
$1.6M
Predisposing Factors for the Development of Atrial Fibrillation Among WomenR21HL093613 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ALBERT, CHRISTINE M · 2009 to 2010
$347k
NCI NIH HHS CA-047988NHLBI NIH HHS HL-043851NHLBI NIH HHS HL-080467NHLBI NIH HHS R21 HL093613
6 · The paper itself

Abstract

backgroundIt is somewhat controversial whether caffeine consumption is associated with an increased risk of developing atrial fibrillation (AF).

objectiveWe prospectively assessed the relation between caffeine intake and incident AF.

designA total of 33,638 initially healthy women who participated in the Women's Health Study and who were gt 45 y of age and free of cardiovascular disease and AF at baseline were prospectively followed for incident AF from 1993 to 2 March 2009. All women provided information on caffeine intake via food-frequency questionnaires at baseline and in 2004.

resultsDuring a median follow-up of 14.4 y (interquartile range: 13.8-14.8 y), 945 AF events occurred. Median caffeine intakes across increasing quintiles of caffeine intake were 22, 135, 285, 402, and 656 mg/d, respectively. Age-adjusted incidence rates of AF across increasing quintiles of caffeine intake were 2.15, 1.89, 2.01, 2.24, and 2.04 events, respectively, per 1000 person-years of follow-up. In Cox proportional hazards models updated in 2004 by using time-varying covariates, the corresponding multivariable-adjusted hazard ratios (95% CI) were 1.0, 0.88 (0.72, 1.06), 0.78 (0.64, 0.95), 0.96 (0.79, 1.16), and 0.89 (0.73, 1.09) (P for linear trend: 0.45). None of the individual components of caffeine intake (coffee, tea, cola, and chocolate) were significantly associated with incident AF.

conclusionsIn this large cohort of initially healthy women, elevated caffeine consumption was not associated with an increased risk of incident AF. Therefore, our data suggest that elevated caffeine consumption does not contribute to the increasing burden of AF in the population. This trial was registered at clinicaltrials.gov as NCT00000479.

Indexed as

Atrial FibrillationBeveragesCaffeineData CollectionFemaleFollow-Up StudiesHumansIncidenceMiddle AgedPlant ExtractsProportional Hazards ModelsSurveys and QuestionnairesCaffeinePlant Extracts

Identifiers

PMID20573799
PMCPMC2921535
OpenAlexW2150445954

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.