Evidence map›Paper›PMID 20573787›Full record

Trial reportThe American journal of clinical nutrition2010

Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects.

Yiming Xia, Kristina E Hill, Ping Li, Jiayuan Xu, Dingyou Zhou, Amy K Motley, Li Wang, Daniel W Byrne, Raymond F Burk

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00428649 (Optimization of Selenoprotein P in Chinese Subjects), which is not on this map. Cited by 101 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 4 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00428649 nacompletednot on this map

Optimization of Selenoprotein P in Chinese Subjects

TypeinterventionalSponsorVanderbilt UniversityRan2007 to 2008Enrolled98ConditionsSelenium DeficiencyArms20 µg selenium, 40 µg selenium, 60 µg selenium, 80 µg selenium, 100 µg selenium
3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 4 syntheses or guidelines pooled it, 230 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Selenium and Coenzyme QNutrients · 2022
    Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Review

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Yiming XiaSichuan Provincial Center for Disease Control and Prevention, Chengdu, China.
Kristina E Hill
Ping Li
Jiayuan Xu
Dingyou Zhou
Amy K Motley
Li Wang
Daniel W Byrne
Raymond F Burk
Vanderbilt University · USSichuan Center for Disease Control and Prevention · CN

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
Human Se Nutritional Requirement and Biomarkers in Health and DiseaseR01DK058763 · NIDDK · VANDERBILT UNIVERSITY · PI BURK, RAYMOND F. · 2001 to 2010
$3.6M
NCRR NIH HHS UL1 RR024975NIDDK NIH HHS R01 DK58763
6 · The paper itself

Abstract

backgroundThe intake of selenium needed for optimal health has not been established. Selenoproteins perform the functions of selenium, and the selenium intake needed for their full expression is not known.

objectiveThis study sought to determine the intake of selenium required to optimize plasma selenoprotein P (SEPP1) and to compare SEPP1 with other plasma selenium biomarkers.

designA 40-wk placebo-controlled, double-blind study of selenium repletion was carried out in 98 healthy Chinese subjects who had a daily dietary selenium intake of 14 micro g. Fourteen subjects each were assigned randomly to daily dose groups of 0, 21, 35, 55, 79, 102, and 125 micro g Se as l-selenomethionine. Plasma glutathione peroxidase (GPX) activity, SEPP1, and selenium were measured. A biomarker was considered to be optimized when its value was not different from the mean value of the subjects receiving larger supplements.

resultsThe SEPP1 concentration was optimized at 40 wk by the 35- micro g supplement, which indicated that 49 micro g/d could optimize it. GPX activity was optimized by 21 micro g (total ingestion: 35 micro g/d). The selenium concentration showed no tendency to become optimized.

conclusionsThe present results indicate that SEPP1 concentration is the best plasma biomarker studied for assessing optimal expression of all selenoproteins, because its optimization required a larger intake of selenium than did GPX activity. On the basis of the selenium intake needed for SEPP1 optimization with adjustments for body weight and individual variation, ap 75 micro g Se/d as selenomethionine is postulated to allow full expression of selenoproteins in US residents. This trial was registered at clinicaltrials.gov as NCT00428649.

Indexed as

Nutritional RequirementsAdultAsian PeopleBiomarkersDouble-Blind MethodGlutathione PeroxidaseHumansSeleniumSelenomethionineSelenoprotein PBiomarkersGlutathione PeroxidaseSeleniumSelenomethionineSelenoprotein P

Identifiers

PMID20573787
PMCPMC2921536
OpenAlexW2151163976

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.