ReviewEndocrinology2010
Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up.
Review in Endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 148 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
148 citing papers in PubMed.
- Effects of Peripheral Neural Blocks in Laparoscopic Sleeve Gastrectomy: a Pilot Study on Cognitive Functions in Severe Obese Patients.Obesity surgery · 2023Trial
- C-Reactive protein in relation to fecundability and anovulation among eumenorrheic women.Fertility and sterility · 2018Trial
- Weight loss aggravates obesity-induced hypothalamic inflammation in mid-aged mice.GeroScience · 2026Article
- The NF-κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets.Journal of cellular and molecular medicine · 2026Review
- Research Advances of Neuroregulatory Effects of Dietary Polyphenols on Obesity Complications.Nutrients · 2026Review
- Comparative Analysis of Hypothalamic Responses to Stress and Glutamine Supplementation in Diet-Induced Obese Mice: A Study of Sex Differences.Inflammation · 2026Article
- Advances in immunological research on male infertility.Frontiers in reproductive health · 2026Review
- The Impact of Air Pollution and Obesity on Cognitive Decline and Risk of Alzheimer's Disease.International journal of molecular sciences · 2025Review
- Endocrine and metabolic consequences of childhood-onset craniopharyngioma during the transition age: A literature review by the TALENT study group.Reviews in endocrine & metabolic disorders · 2025Review
- Sex-dependent effects of a high-fat diet-induced obesity model on cerebrovascular health and brain metabolism.Experimental physiology · 2025Article
- Microglia/macrophage-specific deletion of TLR-4 protects against neural effects of diet-induced obesity in a sexually dimorphic manner.Journal of neuroinflammation · 2025Article
- Heat-InactivatedFoods (Basel, Switzerland) · 2025Article
- The Resistin/TLR4/miR-155-5p axis: a novel signaling pathway in the onset of hypothalamic neuroinflammation.Journal of neuroinflammation · 2025Article
- The Role of Neuroinflammation in the Comorbidity of Psychiatric Disorders and Internal Diseases.Healthcare (Basel, Switzerland) · 2025Review
- Sex-dependent effects of a high-fat diet on the hypothalamic response in mice.Biology of sex differences · 2025Article
- Parkinson's disease and metabolic disorders, understanding their shared co-morbidity through the autonomic nervous system.Advances in genetics · 2025Review
- Relationships between nutritional intake, appetite regulation, and mental health with body composition among female college students with overweight and obesity.Frontiers in psychology · 2025Article
- Neuroendocrine control of glucose homeostasis: integrative mechanisms from the hypothalamus to the brainstem.Frontiers in endocrinology · 2025Review
- Effect of TSH on aromatase expression of ovarian granulosa cells in obese mice.Hormones (Athens, Greece) · 2024Article
- Obesity is associated with alterations in anatomical connectivity of frontal-corpus callosum.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
88 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Obesity induced by high-fat (HF) feeding is associated with low-grade inflammation in peripheral tissues that predisposes to insulin resistance. Recent evidence suggests the occurrence of a similar process in the hypothalamus, which favors weight gain through impairment of leptin and insulin signaling. In addition to its implications for obesity pathogenesis, this hypothesis suggests that centrally targeted antiinflammatory therapies may prove effective in prevention and treatment of this disorder. This article highlights molecular and cellular mechanisms by which hypothalamic inflammation predisposes to diet-induced obesity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.