ArticleProgress in neuro-psychopharmacology & biological psychiatry2010
5-HTTLPR moderates effects of current life events on neuroticism: differential susceptibility to environmental influences.
Article in Progress in neuro-psychopharmacology & biological psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 114 citations in OpenAlex.
- Novel GxE effects and resilience: A case:control longitudinal study of psychosocial stress with war-affected youth.PloS one · 2022Trial
- On the meaning of "plasticity" in neuroscience and mental health research and its relation to the action of psychedelic therapy.Frontiers in neuroscience · 2026Article
- Genetic Susceptibility to the Environment Moderates the Impact of Childhood Experiences on Psychotic, Depressive, and Anxiety Dimensions.Schizophrenia bulletin · 2025Article
- How do fathers' educational level contribute to children's school problems? Overparenting and children's gender and surgency in a moderated mediation model.Frontiers in psychology · 2024Article
- Must one take the bitter with the sweet? Sensory processing sensitivity and factors associated with resilience among artistically inclined individuals.Current psychology (New Brunswick, N.J.) · 2023Article
- RNA epitranscriptomics dysregulation: A major determinant for significantly increased risk of ASD pathogenesis.Frontiers in neuroscience · 2023Article
- The Moderating Role of Surgency, Behavioral Inhibition, Negative Emotionality and Effortful Control in the Relationship between Parenting Style and Children's Reactive and Proactive Aggression.Children (Basel, Switzerland) · 2022Article
- Sensory-processing sensitivity and COVID-19 stress in a young population: The mediating role of resilience.Personality and individual differences · 2022Article
- Serotonergic sensitivity alleles moderate relations between attachment security at age three and socioemotional competence at age five.Developmental psychobiology · 2021Article
- Serotonin transporter gene (SLC6A4) variation and sensory processing sensitivity-Comparison with other anxiety-related temperamental dimensions.Molecular genetics & genomic medicine · 2020Article
- "Out, out, brief candle! Life's but a walking shadow":Frontiers in psychiatry · 2020Article
- Preliminary Evidence That CD38 Moderates the Association of Neuroticism on Amygdala-Subgenual Cingulate Connectivity.Frontiers in neuroscience · 2020Article
- A biocultural approach to psychiatric illnesses.Psychopharmacology · 2019Review
- Puberty and the Evolution of Developmental Science.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2019Review
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- Culture and cannabinoid receptor gene polymorphism interact to influence the perception of happiness.PloS one · 2018Article
- Genetics of generalized anxiety disorder and related traits.Dialogues in clinical neuroscience · 2017Review
- Serotonin Transporter Gene Polymorphisms and Early Parent-Infant Interactions Are Related to Adult Male Heart Rate Response to Female Crying.Frontiers in physiology · 2017Article
- Vulnerability or Sensitivity to the Environment? Methodological Issues, Trends, and Recommendations in Gene-Environment Interactions Research in Human Behavior.Frontiers in psychiatry · 2017Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Research chronicling links between a polymorphism in the serotonin-transporter gene (5-HTTLPR) and neuroticism has yielded inconsistent results. One possible explanation for this inconsistency is that any gene-phenotype association is obscured by a gene-X-environment (GXE) interaction. We studied a healthy non-clinical sample (N=118) to determine whether the 5-HTTLPR interacts with current life events in predicting neuroticism. The differential-susceptibility hypothesis led to the prediction of such an interaction, reflecting the fact that individuals with short alleles would be affected more by both negative and positive life events than those homozygous for long alleles. Participants completed questionnaires concerning recent life events and neuroticism. The 5-HTTLPR was genotyped using a standard protocol with DNA extracted from oral fluid. For those homozygous for the short allele, more negative life events proved related to greater neuroticism, whereas more positive life events proved related to less neuroticism. No such association emerged in the case of those homozygous for the long allele. Whereas neuroticism is likely to be an especially stable trait in individuals homozygous for the long allele, this may be less so the case for those carrying short alleles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.