Trial reportEuropean journal of applied physiology2010
Mitochondrial gene expression in elite cyclists: effects of high-intensity interval exercise.
Trial report in European journal of applied physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Effects of high-intensity interval training on physical morphology, cardiopulmonary function, and metabolic indicators in older adults: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- HIIT vs. SIT: What Is the Better to Improve V˙OInternational journal of environmental research and public health · 2021Pooled it
- Sprint interval training effects on aerobic capacity: a systematic review and meta-analysis.Sports medicine (Auckland, N.Z.) · 2014Pooled it
- Effects of including sprints during prolonged cycling on hormonal and muscular responses and recovery in elite cyclists.Scandinavian journal of medicine & science in sports · 2021Trial
- Metabolic stress-dependent regulation of the mitochondrial biogenic molecular response to high-intensity exercise in human skeletal muscle.The Journal of physiology · 2018Trial
- Exercise duration-matched interval and continuous sprint cycling induce similar increases in AMPK phosphorylation, PGC-1α and VEGF mRNA expression in trained individuals.European journal of applied physiology · 2016Trial
- Sodium bicarbonate ingestion augments the increase in PGC-1α mRNA expression during recovery from intense interval exercise in human skeletal muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Trial
- Trial
- Exercise with low glycogen increases PGC-1α gene expression in human skeletal muscle.European journal of applied physiology · 2013Trial
- Pronounced effects of acute endurance exercise on gene expression in resting and exercising human skeletal muscle.PloS one · 2012Trial
- Comparison of different interval training methods on athletes' oxygen uptake: a systematic review with pairwise and network meta-analysis.BMC sports science, medicine & rehabilitation · 2025Article
- Effect of acute swimming exercise at different intensities but equal total load over metabolic and molecular responses in swimming rats.Journal of muscle research and cell motility · 2022Article
- No Differences Between 12 Weeks of Block- vs. Traditional-Periodized Training in Performance Adaptations in Trained Cyclists.Frontiers in physiology · 2022Article
- Comprehensive Return to Competitive Distance Running: A Clinical Commentary.Sports medicine (Auckland, N.Z.) · 2021Review
- The Muscle-Brain Axis and Neurodegenerative Diseases: The Key Role of Mitochondria in Exercise-Induced Neuroprotection.International journal of molecular sciences · 2021Review
- Ischemic Preconditioning Enhances Aerobic Adaptations to Sprint-Interval Training in Athletes Without Altering Systemic Hypoxic Signaling and Immune Function.Frontiers in sports and active living · 2020Article
- Inclusion of sprints in moderate intensity continuous training leads to muscle oxidative adaptations in trained individuals.Physiological reports · 2019Article
- Biological Background of Block Periodized Endurance Training: A Review.Sports medicine (Auckland, N.Z.) · 2019Review
- Principles of Exercise Prescription, and How They Influence Exercise-Induced Changes of Transcription Factors and Other Regulators of Mitochondrial Biogenesis.Sports medicine (Auckland, N.Z.) · 2018Review
- A compendium of physical exercise-related human genes: an 'omic scale analysis.Biology of sport · 2018Article
Corrections and comments
- Erratum issuedNiklas, Psilander [corrected to Psilander, Niklas]; Li, Wang [corrected to Wang, Li]; Jens, Westergren [corrected to Westergren, Jens]; Michail, Tonkonogi [corrected to Tonkonogi, Michail]; Kent, Sahlin [corrected to Sahlin, Kent]
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known about the effect of training on genetic markers for mitochondrial biogenesis in elite athletes. We tested the hypothesis that low-volume sprint interval exercise (SIE) would be as effective as high-volume interval exercise (IE). Ten male cyclists competing on national elite level (W (max) 403 ± 13 W, VO(2peak) 68 ± 1 mL kg(-1) min(-1)) performed two interval exercise protocols: 7 × 30-s "all-out" bouts (SIE) and 3 × 20-min bouts at ~87% of VO(2peak) (IE). During IE, the work was eightfold larger (1,095 ± 43 vs. 135 ± 5 kJ) and the exercise duration 17 times longer (60 vs. 3.5 min) than during SIE. Muscle samples were taken before and 3 h after exercise. The mRNA of upstream markers of mitochondrial biogenesis [peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1α), PGC-1α-related coactivator (PRC) and peroxisome proliferator-activated receptor δ (PPARδ)] increased to the same extent after SIE and IE (6-, 1.5- and 1.5-fold increase, respectively). Of the downstream targets of PGC-1α, mitochondrial transcription factor A (Tfam) increased only after SIE and was significantly different from that after IE (P < 0.05), whereas others increased to the same extent (pyruvate dehydrogenase kinase, PDK4) or was unchanged (nuclear respiratory factor 2, NRF2). We conclude that upstream genetic markers of mitochondrial biogenesis increase in a similar way in elite athletes after one exercise session of SIE and IE. However, since the volume and duration of work was considerably lower during SIE and since Tfam, the downstream target of PGC-1α, increased only after SIE, we conclude that SIE might be a time-efficient training strategy for highly trained individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.