Evidence map›Paper›PMID 20571541›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2010

A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes.

Dongmei Sun, Xiaoying Zhuang, Xiaoyu Xiang, Yuelong Liu, Shuangyin Zhang, Cunren Liu, Stephen Barnes, William Grizzle, Donald Miller, Huang-Ge Zhang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 771 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
771citing papers in PubMed, 2 pooled it
8.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

771 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,539 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Biology and Therapeutic Potential of Exosomes, Targeted Drug Delivery.International journal of molecular sciences · 2026
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711 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Dongmei SunDepartment of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Xiaoying Zhuang
Xiaoyu Xiang
Yuelong Liu
Shuangyin Zhang
Cunren Liu
Stephen Barnes
William Grizzle
Donald Miller
Huang-Ge Zhang
University of Alabama at Birmingham · USJames Graham Brown Foundation · USUniversity of Louisville · US

Funding

Curcumin reverses tumor exosomes-mediated inhibition of myeloid differentiationR01AT004294 · NCCIH · UNIVERSITY OF LOUISVILLE · PI ZHANG, HUANG-GE · 2007 to 2010
$1.4M
Breast tumor exosomal Jak3BP mediated immunosuppressionR01CA116092 · NCI · UNIVERSITY OF LOUISVILLE · PI ZHANG, HUANG-GE · 2005 to 2011
$1.3M
Age related ubiquitin defect on T-cell response to tumorR01CA107181 · NCI · UNIVERSITY OF LOUISVILLE · PI ZHANG, HUANG-GE · 2005 to 2009
$1.1M
lung tumor exosome-mediated inflammation promotes tumor progression and growthR01CA137037 · NCI · UNIVERSITY OF LOUISVILLE · PI ZHANG, HUANG-GE · 2009 to 2010
$616k
NCCIH NIH HHS R01 AT004294NCCIH NIH HHS R01AT004294NCI NIH HHS R01 CA107181NCI NIH HHS R01CA107181NCI NIH HHS R01 CA116092NCI NIH HHS R01CA116092NCI NIH HHS R01 CA137037NCI NIH HHS R01CA137037
6 · The paper itself

Abstract

Monocyte-derived myeloid cells play vital roles in inflammation-related autoimmune/inflammatory diseases and cancers. Here, we report that exosomes can deliver anti-inflammatory agents, such as curcumin, to activated myeloid cells in vivo. This technology provides a means for anti-inflammatory drugs, such as curcumin, to target the inflammatory cells as well as to overcome unwanted off-target effects that limit their utility. Using exosomes as a delivery vehicle, we provide evidence that curcumin delivered by exosomes is more stable and more highly concentrated in the blood. We show that the target specificity is determined by exosomes, and the improvement of curcumin activity is achieved by directing curcumin to inflammatory cells associated with therapeutic, but not toxic, effects. Furthermore, we validate the therapeutic relevance of this technique in a lipopolysaccharide (LPS)-induced septic shock mouse model. We further show that exosomes, but not lipid alone, are required for the enhanced anti-inflammatory activity of curcumin. The specificity of using exosomes as a drug carrier creates opportunities for treatments of many inflammation-related diseases without significant side effects due to innocent bystander or off-target effects.

Indexed as

AnimalsAnti-Inflammatory AgentsBlotting, WesternCell Line, TumorCells, CulturedCurcuminDrug CarriersExosomesFemaleFlow CytometryLipopolysaccharidesMiceMice, Inbred C57BLNanoparticlesShock, SepticAnti-Inflammatory AgentsCurcuminDrug CarriersLipopolysaccharides

Identifiers

PMID20571541
PMCPMC2956928
OpenAlexW2166846320

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.