ArticleMolecular systems biology2010
Violations of robustness trade-offs.
Article in Molecular systems biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Performance and robustness analysis reveals phenotypic trade-offs in yeast.Life science alliance · 2024Article
- Article
- Quantification of Microbial Robustness in Yeast.ACS synthetic biology · 2022Article
- Clinical Applications of System Regulation Medicine.Open access Macedonian journal of medical sciences · 2019Review
- Seasonal variation modulates coral sensibility to heat-stress and explains annual changes in coral productivity.Scientific reports · 2017Article
- A Statistical Approach Reveals Designs for the Most Robust Stochastic Gene Oscillators.ACS synthetic biology · 2016Article
- Noise Reduction in Complex Biological Switches.Scientific reports · 2016Article
- Pervasive robustness in biological systems.Nature reviews. Genetics · 2015Review
- Simplified mechanistic models of gene regulation for analysis and design.Journal of the Royal Society, Interface · 2015Article
- Therapeutic control and resistance of the EGFR-driven signaling network in glioblastoma.Cell communication and signaling : CCS · 2015Review
- Quantitative Analysis of Robustness of Dynamic Response and Signal Transfer in Insulin mediated PI3K/AKT Pathway.Computers & chemical engineering · 2014Article
- A Chemical Engineer's Perspective on Health and Disease.Computers & chemical engineering · 2014Article
- Composing problem solvers for simulation experimentation: a case study on steady state estimation.PloS one · 2014Article
- A Systems Engineering Perspective on Homeostasis and Disease.Frontiers in bioengineering and biotechnology · 2013Review
- The bottom-up approach to defining life: deciphering the functional organization of biological cells via multi-objective representation of biological complexity from molecules to cells.Frontiers in physiology · 2013Article
- Hierarchical modularity and the evolution of genetic interactomes across species.Molecular cell · 2012Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biological robustness is a principle that may shed light on system-level characteristics of biological systems. One intriguing aspect of the concept of biological robustness is the possible existence of intrinsic trade-offs among robustness, fragility, performance, and so on. At the same time, whether such trade-offs hold regardless of the situation or hold only under specific conditions warrants careful investigation. In this paper, we reassess this concept and argue that biological robustness may hold only when a system is sufficiently optimized and that it may not be conserved when there is room for optimization in its design. Several testable predictions and implications for cell culture experiments are presented.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.