ArticleMolecular systems biology2010
A modular gradient-sensing network for chemotaxis in Escherichia coli revealed by responses to time-varying stimuli.
Article in Molecular systems biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers.
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Who cites it
150 citing papers in PubMed.
- Article
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- Carbon-phosphorus exchange rate constrains density-speed trade-off in arbuscular mycorrhizal fungal growth.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Spontaneous switching in a protein signalling array reveals near-critical cooperativity.Nature physics · 2026Article
- Single-array measurements reveal non-uniform, mosaic-like chemosensory arrays in bacteria.Nature communications · 2025Article
- ChemotaxingbioRxiv : the preprint server for biology · 2025Article
- ChemotaxingArXiv · 2025Article
- Identification of the governing equation of stimulus-response data for run-and-tumble dynamics.PLoS computational biology · 2025Article
- Experimental evolution partially restores functionality of bacterial chemotaxis network with reduced number of components.PLoS genetics · 2025Article
- Actionable Forecasting as a Determinant of Biological Adaptation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Temporal Contrastive Learning through implicit non-equilibrium memory.Nature communications · 2025Article
- A structural perspective on insect gustatory receptors.Chemical senses · 2025Review
- Article
- Optimal Cell Length for Exploration and Exploitation in Chemotactic Planktonic Bacteria.Environmental microbiology · 2024Article
- Combined response of polar magnetotaxis to oxygen and pH: Insights from hanging drop assays and microcosm experiments.Scientific reports · 2024Article
- Time-reversal symmetry breaking in the chemosensory array reveals a general mechanism for dissipation-enhanced cooperative sensing.Nature communications · 2024Article
- A biological circuit to anticipate trend.Evolution letters · 2024Article
- Signal integration and adaptive sensory diversity tuning in Escherichia coli chemotaxis.Cell systems · 2024Article
- Signal integration in chemoreceptor complexes.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Flagellar dynamics reveal fluctuations and kinetic limit in the Escherichia coli chemotaxis network.Scientific reports · 2023Article
90 more citing papers are in PubMed but not listed here.
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3 authors.
Funding
Abstract
The Escherichia coli chemotaxis-signaling pathway computes time derivatives of chemoeffector concentrations. This network features modules for signal reception/amplification and robust adaptation, with sensing of chemoeffector gradients determined by the way in which these modules are coupled in vivo. We characterized these modules and their coupling by using fluorescence resonance energy transfer to measure intracellular responses to time-varying stimuli. Receptor sensitivity was characterized by step stimuli, the gradient sensitivity by exponential ramp stimuli, and the frequency response by exponential sine-wave stimuli. Analysis of these data revealed the structure of the feedback transfer function linking the amplification and adaptation modules. Feedback near steady state was found to be weak, consistent with strong fluctuations and slow recovery from small perturbations. Gradient sensitivity and frequency response both depended strongly on temperature. We found that time derivatives can be computed by the chemotaxis system for input frequencies below 0.006 Hz at 22 degrees C and below 0.018 Hz at 32 degrees C. Our results show how dynamic input-output measurements, time honored in physiology, can serve as powerful tools in deciphering cell-signaling mechanisms.
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