ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2011
Intact memory in TGF-β1 transgenic mice featuring chronic cerebrovascular deficit: recovery with pioglitazone.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04058132 (Cerebrovascular Reactivity), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cerebrovascular Reactivity (CVR) Assessed With Functional Near Infrared Spectroscopy (fNIRS) as a Biomarker of Traumatic Cerebrovascular Injury (TCVI) Measured Longitudinally After Acute TBI in Military Personnel
Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Alzheimer's disease and cerebrovascular pathology alter inward rectifier potassium (KBritish journal of pharmacology · 2022Article
- TGF-β Signaling: A Therapeutic Target to Reinstate Regenerative Plasticity in Vascular Dementia?Aging and disease · 2020Review
- Comparative benefits of simvastatin and exercise in a mouse model of vascular cognitive impairment and dementia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- High cholesterol triggers white matter alterations and cognitive deficits in a mouse model of cerebrovascular disease: benefits of simvastatin.Cell death & disease · 2019Article
- TGFβ pathway deregulation and abnormal phospho-SMAD2/3 staining in hereditary cerebral hemorrhage with amyloidosis-Dutch type.Brain pathology (Zurich, Switzerland) · 2018Article
- Imaging of Cerebrovascular Function in Chronic Traumatic Brain Injury.Journal of neurotrauma · 2018Article
- Phosphodiesterase-5 inhibition potentiates cerebrovascular reactivity in chronic traumatic brain injury.Annals of clinical and translational neurology · 2018Article
- Simvastatin restored vascular reactivity, endothelial function and reduced string vessel pathology in a mouse model of cerebrovascular disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Sex differences in TGFB-β signaling with respect to age of onset and cognitive functioning in schizophrenia.Neuropsychiatric disease and treatment · 2015Article
- Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment.Cell death and differentiation · 2014Article
- Endothelial TRPV4 channels mediate dilation of cerebral arteries: impairment and recovery in cerebrovascular pathologies related to Alzheimer's disease.British journal of pharmacology · 2013Article
- Neurovascular abnormalities in brain disorders: highlights with angiogenesis and magnetic resonance imaging studies.Journal of biomedical science · 2013Review
- Using genetics to enable studies on the prevention of Alzheimer's disease.Clinical pharmacology and therapeutics · 2013Article
- Article
- Pathophysiology of the neurovascular unit: disease cause or consequence?Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Review
- Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The neuroprotective functions of transforming growth factor beta proteins.International journal of molecular sciences · 2012Article
- Neurovascular function in Alzheimer's disease patients and experimental models.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2011Review
- Protecting against vascular disease in brain.American journal of physiology. Heart and circulatory physiology · 2011Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The roles of chronic brain hypoperfusion and transforming growth factor-beta 1 (TGF-β1) in Alzheimer's disease (AD) are unresolved. We investigated the interplay between TGF-β1, cerebrovascular function, and cognition using transgenic TGF mice featuring astrocytic TGF-β1 overexpression. We further assessed the impact of short, late therapy in elderly animals with the antioxidant N-acetyl-L-cysteine (NAC) or the peroxisome proliferator-activated receptor-γ agonist pioglitazone. The latter was also administered to pups as a prophylactic 1-year treatment. Elderly TGF mice featured cerebrovascular dysfunction that was not remedied with NAC. In contrast, pioglitazone prevented or reversed this deficit, and rescued the impaired neurovascular coupling response to whisker stimulation, although it failed to normalize the vascular structure. In aged TGF mice, neuronal and cognitive indices--the stimulus-evoked neurometabolic response, cortical cholinergic innervation, and spatial memory in the Morris water maze--were intact. Our findings show that impaired brain hemodynamics and cerebrovascular function are not accompanied by memory impairment in this model. Conceivably in AD, they constitute aggravating factors against a background of aging and underlying pathology. Our data further highlight the ability of pioglitazone to protect the cerebrovasculature marked by TGF-β1 increase, aging, fibrosis, and antioxidant resistance, thus of high relevance for AD patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.