ArticleEuropean journal of human genetics : EJHG2010
Population structure and genome-wide patterns of variation in Ireland and Britain.
Article in European journal of human genetics : EJHG, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Declining autozygosity over time: An exploration in over 1 million individuals from three diverse cohorts.American journal of human genetics · 2023Pooled it
- A genetic perspective on the recent demographic history of Ireland and Britain.European journal of human genetics : EJHG · 2025Article
- Usher Syndrome on the Island of Ireland: A Genotype-Phenotype Review.Investigative ophthalmology & visual science · 2023Article
- Article
- Insular Celtic population structure and genomic footprints of migration.PLoS genetics · 2018Article
- The Irish DNA Atlas: Revealing Fine-Scale Population Structure and History within Ireland.Scientific reports · 2017Article
- Weighted likelihood inference of genomic autozygosity patterns in dense genotype data.BMC genomics · 2017Article
- Regional surnames and genetic structure in Great Britain.Transactions (Institute of British Geographers : 1965) · 2016Article
- Genetic structure of the Newfoundland and Labrador population: founder effects modulate variability.European journal of human genetics : EJHG · 2016Article
- Iron Age and Anglo-Saxon genomes from East England reveal British migration history.Nature communications · 2016Article
- Recent genomic heritage in Scotland.BMC genomics · 2015Article
- Fine-scale human genetic structure in Western France.European journal of human genetics : EJHG · 2015Article
- Article
- No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset.Schizophrenia research · 2014Article
- Genetic characterization of northeastern Italian population isolates in the context of broader European genetic diversity.European journal of human genetics : EJHG · 2013Article
- The geography of recent genetic ancestry across Europe.PLoS biology · 2013Article
- A genome-wide analysis of populations from European Russia reveals a new pole of genetic diversity in northern Europe.PloS one · 2013Article
- Small effective population size and genetic homogeneity in the Val Borbera isolate.European journal of human genetics : EJHG · 2013Article
- Genomic patterns of homozygosity in worldwide human populations.American journal of human genetics · 2012Article
- People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population.European journal of human genetics : EJHG · 2012Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Located off the northwestern coast of the European mainland, Britain and Ireland were among the last regions of Europe to be colonized by modern humans after the last glacial maximum. Further, the geographical location of Britain, and in particular of Ireland, is such that the impact of historical migration has been minimal. Genetic diversity studies applying the Y chromosome and mitochondrial systems have indicated reduced diversity and an increased population structure across Britain and Ireland relative to the European mainland. Such characteristics would have implications for genetic mapping studies of complex disease. We set out to further our understanding of the genetic architecture of the region from the perspective of (i) population structure, (ii) linkage disequilibrium (LD), (iii) homozygosity and (iv) haplotype diversity (HD). Analysis was conducted on 3654 individuals from Ireland, Britain (with regional sampling in Scotland), Bulgaria, Portugal, Sweden and the Utah HapMap collection. Our results indicate a subtle but clear genetic structure across Britain and Ireland, although levels of structure were reduced in comparison with average cross-European structure. We observed slightly elevated levels of LD and homozygosity in the Irish population compared with neighbouring European populations. We also report on a cline of HD across Europe with greatest levels in southern populations and lowest levels in Ireland and Scotland. These results are consistent with our understanding of the population history of Europe and promote Ireland and Scotland as relatively homogenous resources for genetic mapping of rare variants.
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