Trial reportEuropean journal of clinical nutrition2010
Vitamin B(6) supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis.
Trial report in European journal of clinical nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 128 citations in OpenAlex.
- Pooled it
- Effect of vitamin B6 on pain, disease severity, and psychological profile of fibromyalgia patients; a randomized, double-blinded clinical trial.BMC musculoskeletal disorders · 2022Trial
- Trial
- Association between patterns of circulating vitamin co-exposure and the prognosis of rheumatoid arthritis.Clinical rheumatology · 2026Article
- Exploring the link between water-soluble vitamins and aging-associated immune system status.Frontiers in immunology · 2026Review
- Relationship between serum pyridoxal 5'-phosphate concentration and cognitive function in older Japanese.Journal of clinical biochemistry and nutrition · 2025Article
- Evaluating the link between the dietary intake of vitamin B and constipation: a population-based study.Frontiers in nutrition · 2025Article
- Hyperhomocysteinemia in Takayasu arteritis-genetically defined or burden of the proinflammatory state?Frontiers in immunology · 2025Article
- The Effectiveness and Safety of a Nutraceutical Combination in Overweight Patients with Metabolic Syndrome.Nutrients · 2024Observational
- Dietary fibers boost gut microbiota-produced B vitamin pool and alter host immune landscape.Microbiome · 2024Article
- Electrochemical sensing of vitamin BScientific reports · 2024Article
- Vitamin B6 alleviates osteoarthritis by suppressing inflammation and apoptosis.BMC musculoskeletal disorders · 2024Article
- PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity.Nature metabolism · 2024Article
- A systems biology-based mathematical model demonstrates the potential anti-stress effectiveness of a multi-nutrient botanical formulation.Scientific reports · 2024Article
- Factors influencing vitamin B6 status in domestic cats: age, disease, and body condition score.Scientific reports · 2024Article
- Association between vitamin B6 levels and rheumatoid arthritis: a two-sample Mendelian randomization study.Frontiers in nutrition · 2024Article
- Impact of lifestyle factors on dietary vitamin BThe British journal of nutrition · 2023Article
- High-Dose Vitamin B6 (Pyridoxine) Displays Strong Anti-Inflammatory Properties in Lipopolysaccharide-Stimulated Monocytes.Biomedicines · 2023Article
- Management of a Patient With Premenstrual Syndrome Using Acupuncture, Supplements, and Meditation: A Case Report.Journal of chiropractic medicine · 2023Article
- How Do Minerals, Vitamins, and Intestinal Microbiota Affect the Development and Progression of Heart Disease in Adult and Pediatric Patients?Nutrients · 2023Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesThe purpose of this study was to investigate whether vitamin B(6) supplementation had a beneficial effect on inflammatory and immune responses in patients with rheumatoid arthritis (RA). SUBJECTS/
methodsThis was a single-blind co-intervention study performed at the Division of Allergy, Immunology and Rheumatology of Chung Shan Medical University Hospital, Taiwan. Patients were diagnosed with RA according to the 1991 American College of Rheumatology criteria for RA. Patients were randomly allocated into two groups: control (5 mg/day folic acid only; n=15) or vitamin B(6) (5 mg/day folic acid plus 100 mg/day vitamin B(6); n=20) for 12 weeks. Plasma pyridoxal 5'-phosphate (PLP), serum folate, inflammatory parameters (that is, high-sensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha)) and immune parameters (that is, white blood cell, total lymphocyte, T-cell (CD3), B-cell (CD19), T-helper cell (CD4), T-suppressor (CD8)) were measured on day 1 (week 0) and after 12 weeks (week 12) of the intervention.
resultsIn the group receiving vitamin B(6), plasma IL-6 and TNF-alpha levels significantly decreased at week 12. There were no significant changes with respect to immune responses in both groups except for the percentage of total lymphocytes in the vitamin B(6) group when compared with week 0 and week 12. Plasma IL-6 level remained significantly inversely related to plasma PLP after adjusting for confounders (beta=-0.01, P=0.01).
conclusionsA large dose of vitamin B(6) supplementation (100 mg/day) suppressed pro-inflammatory cytokines (that is, IL-6 and TNF-alpha) in patients with RA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.