ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2011
Affective cognition and its disruption in mood disorders.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
141 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Facial emotion recognition deficits in bipolar disorder: A systematic review and meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2026Pooled it
- Comparative effectiveness of physical exercise interventions on sociability and communication in children and adolescents with autism: a systematic review and network meta-analysis.BMC psychology · 2024Pooled it
- A neurocognitive model of perceptual decision-making on emotional signals.Human brain mapping · 2020Pooled it
- Balancing act: Neural correlates of affect dysregulation in youth depression and substance use - A systematic review of functional neuroimaging studies.Developmental cognitive neuroscience · 2020Pooled it
- Neural pathways of maternal responding: systematic review and meta-analysis.Archives of women's mental health · 2019Pooled it
- Functional brain responses to emotional faces after three to five weeks of intake of escitalopram in healthy individuals: a double-blind, placebo-controlled randomised study.Scientific reports · 2024Trial
- Effect of Tryptophan Depletion on Conditioned Threat Memory Expression: Role of Intolerance of Uncertainty.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Trial
- Serotonin differentially modulates the temporal dynamics of the limbic response to facial emotions in male adults with and without autism spectrum disorder (ASD): a randomised placebo-controlled single-dose crossover trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Automatic Recognition of Posed Facial Expression of Emotion in Individuals with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2019Trial
- Effects of acute systemic inflammation on the interplay between sad mood and affective cognition.Translational psychiatry · 2017Trial
- Guanfacine modulates the emotional biasing of amygdala-prefrontal connectivity for cognitive control.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2014Trial
- fMRI response to negative words and SSRI treatment outcome in major depressive disorder: a preliminary study.Psychiatry research · 2013Trial
- Trial
- Fronto-limbic function in unaffected offspring at familial risk for bipolar disorder during an emotional working memory paradigm.Developmental cognitive neuroscience · 2013Trial
- Guanfacine modulates the influence of emotional cues on prefrontal cortex activation for cognitive control.Psychopharmacology · 2013Trial
- Temperature discomfort impairs everyday cognition: a pilot study using smartwatch-based ecological momentary assessment.Environmental research communications · 2026Article
- The Specificity of Individuals with Depressive Tendencies in Processing Verbal Emotional Information: Evidence from ERP.Behavioral sciences (Basel, Switzerland) · 2026Article
- Functional bipartition of medial prefrontal cortex into salience detection and movement gain.bioRxiv : the preprint server for biology · 2026Article
- Article
- Amygdala reactivity to threat, negative facial perception, and risk of future psychiatric hospitalizations: a longitudinal study in major depressive and bipolar disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
81 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
In this review, we consider affective cognition, responses to emotional stimuli occurring in the context of cognitive evaluation. In particular, we discuss emotion categorization, biasing of memory and attention, as well as social/moral emotion. We discuss limited neuropsychological evidence suggesting that affective cognition depends critically on the amygdala, ventromedial frontal cortex, and the connections between them. We then consider neuroimaging studies of affective cognition in healthy volunteers, which have led to the development of more sophisticated neural models of these processes. Disturbances of affective cognition are a core and specific feature of mood disorders, and we discuss the evidence supporting this claim, both from behavioral and neuroimaging perspectives. Serotonin is considered to be a key neurotransmitter involved in depression, and there is a considerable body of research exploring whether serotonin may mediate disturbances of affective cognition. The final section presents an overview of this literature and considers implications for understanding the pathophysiology of mood disorder as well as developing and evaluating new treatment strategies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.