ArticleJournal of acquired immune deficiency syndromes (1999)2010
Youth-specific considerations in the development of preexposure prophylaxis, microbicide, and vaccine research trials.
Article in Journal of acquired immune deficiency syndromes (1999), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Brief Report: Phase IIa Safety Study of a Vaginal Ring Containing Dapivirine in Adolescent Young Women.Journal of acquired immune deficiency syndromes (1999) · 2020Trial
- Phase 1 randomized trial of the vaginal safety and acceptability of SPL7013 gel (VivaGel) in sexually active young women (MTN-004).AIDS (London, England) · 2011Trial
- Adolescent and Parent Perceptions about Participation in Biomedical Sexual Health Trials.Ethics & human research · 2020Article
- Advancing HIV Biomedical Prevention Research for At-Risk Adolescents.Journal of acquired immune deficiency syndromes (1999) · 2018Article
- HIV Rates Are Increasing in Gay/Bisexual Teens: IRB Barriers to Research Must Be Resolved to Bend the Curve.American journal of preventive medicine · 2016Article
- Self-Consent for HIV Prevention Research Involving Sexual and Gender Minority Youth: Reducing Barriers Through Evidence-Based Ethics.Journal of empirical research on human research ethics : JERHRE · 2016Article
- Ethical Issues in Adolescents' Sexual and Reproductive Health Research in Nigeria.Developing world bioethics · 2015Review
- Evaluation of an intervention among adolescents to reduce preventive misconception in HIV vaccine clinical trials.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2014Article
- The impact of rapid HIV home test use with sexual partners on subsequent sexual behavior among men who have sex with men.AIDS and behavior · 2014Article
- Preventive misconception and adolescents' knowledge about HIV vaccine trials.Journal of medical ethics · 2013Article
- PrEP awareness and perceived barriers among single young men who have sex with men.Current HIV research · 2013Article
- Substantial multiclass transmitted drug resistance and drug-relevant polymorphisms among treatment-naïve behaviorally HIV-infected youth.AIDS patient care and STDs · 2012Article
- Routine HIV testing in adolescents and young adults presenting to an outpatient clinic in Durban, South Africa.PloS one · 2012Article
- Willingness to participate in biomedical HIV prevention studies after the HVTN 503/Phambili trial: a survey conducted among adolescents in Soweto, South Africa.Journal of acquired immune deficiency syndromes (1999) · 2011Article
- Rectal microbicides: can we make them and will people use them?AIDS and behavior · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
Abstract
Preventing HIV infection in adolescents and young adults will require a multimodal targeted approach, including individual-directed behavioral risk reduction, community-level structural change, and biomedical interventions to prevent sexual transmission. Trials testing biomedical interventions to prevent HIV transmission will require special attention in this population due to the unique psychosocial and physiologic characteristics that differentiate them from older populations. For example, microbicide research will need to consider acceptability, dosing requirements, and coinfection rates that are unique to this population. Preexposure prophylaxis studies also will need to consider potential unique psychosocial issues such as sexual disinhibition and acceptability as well as unique pharmacokinetic parameters of antiretroviral agents. Vaccine trials also face unique issues with this population, including attitudes toward vaccines, risks related to false-positive HIV tests related to vaccine, and different immune responses based on more robust immunity. In this article, we will discuss issues around implementing each of these biomedical prevention modalities in trials among adolescents and young adults to help to guide future successful research targeting this population.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.