ArticleBehavioural pharmacology2010
Withdrawal from chronic exposure to amphetamine, but not nicotine, leads to an immediate and enduring deficit in motivated behavior without affecting social interaction in rats.
Article in Behavioural pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Mapping anhedonia-specific dysfunction in a transdiagnostic approach: an ALE meta-analysis.Brain imaging and behavior · 2016Pooled it
- Association between nicotine withdrawal and reward responsiveness in humans and rats.JAMA psychiatry · 2014Trial
- A new two-hit animal model for schizophrenia research: Consequences on social behavior.IBRO neuroscience reports · 2025Article
- Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder.Current pharmaceutical design · 2020Review
- The effects of acute stress on consummatory and motivational responses for sucrose in rats after long-term withdrawal from morphine.Psychopharmacology · 2019Article
- The interactive effects of ketamine and ethanol on dopamine expression in the ventral tegmental area of rats.Neuropsychiatric disease and treatment · 2018Article
- Acute stress worsens the deficits in appetitive behaviors for social and sexual stimuli displayed by rats after long-term withdrawal from morphine.Psychopharmacology · 2017Article
- The consummatory and motivational behaviors for natural rewards following long-term withdrawal from morphine: no anhedonia but persistent maladaptive behaviors for high-value rewards.Psychopharmacology · 2017Article
- Drug Abuse and Psychosis: New Insights into Drug-induced Psychosis.Experimental neurobiology · 2017Review
- Risky choice and brain CRF after adolescent ethanol vapor exposure and social stress in adulthood.Behavioural brain research · 2016Article
- Withdrawal from Acute Amphetamine Induces an Amygdala-Driven Attenuation of Dopamine Neuron Activity: Reversal by Ketamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Negative affective states and cognitive impairments in nicotine dependence.Neuroscience and biobehavioral reviews · 2015Review
- Cocaine withdrawal in rats selectively bred for low (LoS) versus high (HiS) saccharin intake.Pharmacology, biochemistry, and behavior · 2015Article
- Reconceptualizing anhedonia: novel perspectives on balancing the pleasure networks in the human brain.Frontiers in behavioral neuroscience · 2015Review
- Food consumption and weight gain after cessation of chronic amphetamine administration.Appetite · 2014Article
- Social interaction and social withdrawal in rodents as readouts for investigating the negative symptoms of schizophrenia.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2014Review
- Anhedonia, avolition, and anticipatory deficits: assessments in animals with relevance to the negative symptoms of schizophrenia.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2014Review
- Biological substrates of addiction.Wiley interdisciplinary reviews. Cognitive science · 2014Review
- Complex motivated behaviors for natural rewards following a binge-like regimen of morphine administration: mixed phenotypes of anhedonia and craving after short-term withdrawal.Frontiers in behavioral neuroscience · 2014Article
- Increased impulsive choice for saccharin during PCP withdrawal in female monkeys: influence of menstrual cycle phase.Psychopharmacology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Psychostimulant withdrawal leads to depressive symptoms, such as anhedonia and social dysfunction. We determined the effects of withdrawal from chronic exposure to nicotine (9 mg/kg/day salt, 28 days) or amphetamine (10 mg/kg/day salt, 7 days) on the motivated response for a sucrose reward and on social interaction in rats. Both nicotine and amphetamine exposure increased the motivated response for sucrose. However, only spontaneous amphetamine withdrawal led to an immediate and persistent decrease in motivated behavior, which was not correlated with body weight loss. Social interaction was not affected during withdrawal from either drug. These results indicate that withdrawal from chronic amphetamine exposure leads to an immediate and enduring anhedonic state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.