Evidence map›Paper›PMID 20571289›Full record

ArticleSkin pharmacology and physiology2010

Sun-induced changes in stratum corneum function are gender and dose dependent in a Chinese population.

Z Liu, J W Fluhr, S P Song, Z Sun, H Wang, Y J Shi, P M Elias, M-Q Man

Open access · bronzeAbstract read
In one paragraph

Article in Skin pharmacology and physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 35 citations in OpenAlex.

  1. Low Humidity Alters Epidermal Gene Expression in vivo.Clinical, cosmetic and investigational dermatology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Z LiuDalian Skin Disease Hospital, Liaoning, PR China.
J W Fluhr
S P Song
Z Sun
H Wang
Y J Shi
P M Elias
M-Q Man
Shanghai Skin Disease Hospital · CNDalian Medical University · CNUniversity of California, San Francisco · USInštitut Bion · SI

Funding

NATURE OF THE MAMMALIAN CUTANEOUS PERMEABILITY BARRIERR01AR019098 · NIAMS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI ELIAS, PETER M · 1986 to 2012
$4.2M
NIAMS NIH HHS AR 19098NIAMS NIH HHS R01 AR019098
6 · The paper itself

Abstract

Previous studies have demonstrated that UVB radiation changes the epidermal permeability barrier and stratum corneum (SC) hydration. It is well known that sun exposure causes erythema, sunburn and melanoma. However, whether daily sun exposure alters SC integrity and epidermal permeability barrier function is largely unknown, especially in Chinese subjects. In the present study, we assess the SC integrity, SC hydration and epidermal permeability barrier function following various doses of sun exposure. A total of 258 subjects (124 males and 134 females) aged 18-50 years were enrolled. A multifunctional skin physiology monitor (Courage & Khazaka MPA5) was used to measure SC hydration and transepidermal water loss (TEWL) on the forearms. In males, basal TEWL was higher with higher doses of sun exposure than with lower doses and control, whereas in females, basal TEWL was higher with lower doses of sun exposure than with higher doses and control. In the group with higher doses of sun exposure, TEWL in females was significantly lower than that in males. The barrier recovery was faster in females than in males in both control and lower-dose groups. In both males and females, barrier recovery was delayed with higher doses of sun exposure. In males, sun exposure did not alter SC hydration, while in females SC hydration was lower with lower doses of sun exposure as compared with control and higher doses of sun exposure. These results demonstrated that sun-induced changes in SC function and SC hydration vary with gender and the extent of sun exposure.

Indexed as

AdolescentAdultAsian PeopleDose-Response Relationship, RadiationEpidermisFemaleHumansMaleMiddle AgedPermeabilitySex CharacteristicsSkinSkin Physiological PhenomenaSunlightUltraviolet RaysWater Loss, Insensible

Identifiers

PMID20571289
PMCPMC2968765
OpenAlexW2004597198

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.