ArticleNucleic acids research2010
BRG1 co-localizes with DNA replication factors and is required for efficient replication fork progression.
Article in Nucleic acids research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 58 citations in OpenAlex.
- SMARCA4 regulates SMARCAD1 expression for toleration of replication stress in non-small cell lung cancer.Fujita medical journal · 2026Article
- Srcap Chromatin Remodeler Is Required for Efficient Replication Dynamics in Mammalian Cells.International journal of molecular sciences · 2025Article
- Oncogenic virus hijacks SOX18 pioneer function to enhance viral persistence.Research square · 2025Article
- TRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling.Molecular cell · 2025Article
- Evaluation of two new antibodies for recognition of CldU in DNA fiber assay applications.microPublication biology · 2025Article
- Targeting SWI/SNF Complexes in Cancer: Pharmacological Approaches and Implications.Epigenomes · 2024Review
- Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness.Nature communications · 2022Article
- Bromodomain proteins: protectors against endogenous DNA damage and facilitators of genome integrity.Experimental & molecular medicine · 2021Review
- The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription-replication conflicts.Nature genetics · 2021Article
- ARID1A regulates R-loop associated DNA replication stress.PLoS genetics · 2021Article
- BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency.Cancer research · 2020Article
- Article
- Article
- Single-Molecule DNA Fiber Analyses to Characterize Replication Fork Dynamics in Living Cells.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Review
- Article
- Facilitation of base excision repair by chromatin remodeling.DNA repair · 2015Review
- Understanding replication fork progression, stability, and chromosome fragility by exploiting the Suppressor of Underreplication protein.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Article
- Opposing calcium-dependent signalling pathways control skeletal muscle differentiation by regulating a chromatin remodelling enzyme.Nature communications · 2015Article
- Regulation of Mec1 kinase activity by the SWI/SNF chromatin remodeling complex.Genes & development · 2015Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
For DNA replication to occur, chromatin must be remodeled. Yet, we know very little about which proteins alter nucleosome occupancy at origins and replication forks and for what aspects of replication they are required. Here, we demonstrate that the BRG1 catalytic subunit of mammalian SWI/SNF-related complexes co-localizes with origin recognition complexes, GINS complexes, and proliferating cell nuclear antigen at sites of DNA replication on extended chromatin fibers. The specific pattern of BRG1 occupancy suggests it does not participate in origin selection but is involved in the firing of origins and the process of replication elongation. This latter function is confirmed by the fact that Brg1 mutant mouse embryos and RNAi knockdown cells exhibit a 50% reduction in replication fork progression rates, which is associated with decreased cell proliferation. This novel function of BRG1 is consistent with its requirement during embryogenesis and its role as a tumor suppressor to maintain genome stability and prevent cancer.
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Registered trials
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