ArticleDevelopment (Cambridge, England)2010
Crooked, coiled and crimpled are three Ly6-like proteins required for proper localization of septate junction components.
Article in Development (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 61 citations in OpenAlex.
- Article
- Hematopoietic plasticity mapped ineLife · 2022Review
- Septate junction proteins are required for cell shape changes, actomyosin reorganization and cell adhesion during dorsal closure inFrontiers in cell and developmental biology · 2022Article
- Article
- Hemocyte Clusters Defined by scRNA-Seq inFrontiers in immunology · 2022Article
- Expanding the Junction: New Insights into Non-Occluding Roles for Septate Junction Proteins during Development.Journal of developmental biology · 2021Review
- The ESCRT machinery regulates retromer-dependent transcytosis of septate junction components ineLife · 2020Article
- Genomic analyses of a livestock pest, the New World screwworm, find potential targets for genetic control programs.Communications biology · 2020Article
- Comparative Transcriptomics Provides Insights into Reticulate and Adaptive Evolution of a Butterfly Radiation.Genome biology and evolution · 2019Article
- Article
- Evolution and Medical Significance of LU Domain-Containing Proteins.International journal of molecular sciences · 2019Review
- QTL mapping of natural variation reveals that the developmental regulator bruno reduces tolerance to P-element transposition in the Drosophila female germline.PLoS biology · 2018Article
- Transcriptional effects of a positive feedback circuit in Drosophila melanogaster.BMC genomics · 2017Article
- Diverse Cis-Regulatory Mechanisms Contribute to Expression Evolution of Tandem Gene Duplicates.Molecular biology and evolution · 2017Article
- Article
- Boudin trafficking reveals the dynamic internalisation of specific septate junction components in Drosophila.PloS one · 2017Article
- Occluding junctions of invertebrate epithelia.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Review
- Transcriptional cellular responses in midgut tissue of Aedes aegypti larvae following intoxication with Cry11Aa toxin from Bacillus thuringiensis.BMC genomics · 2015Article
- Identification and expression of an uncharacterized Ly-6 gene cluster in zebrafish Danio rerio.Functional & integrative genomics · 2015Article
- Pasiflora proteins are novel core components of the septate junction.Development (Cambridge, England) · 2015Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Cellular junction formation is an elaborate process that is dependent on the regulated synthesis, assembly and membrane targeting of constituting components. Here, we report on three Drosophila Ly6-like proteins essential for septate junction (SJ) formation. SJs provide a paracellular diffusion barrier and appear molecularly and structurally similar to vertebrate paranodal septate junctions. We show that Crooked (Crok), a small GPI-anchored Ly6-like protein, is required for septa formation and barrier functions. In embryos that lack Crok, SJ components are produced but fail to accumulate at the plasma membrane. Crok is detected in intracellular puncta and acts tissue-autonomously, which suggests that it resides in intracellular vesicles to assist the cell surface localization of SJ components. In addition, we demonstrate that two related Ly6 proteins, Coiled (Cold) and Crimpled (Crim), are required for SJ formation and function in a tissue-autonomous manner, and that Cold also localizes to intracellular vesicles. Specifically, Crok and Cold are required for correct membrane trafficking of Neurexin IV, a central SJ component. The non-redundant requirement for Crok, Cold, Crim and Boudin (Bou; another Ly6 protein that was recently shown to be involved in SJ formation) suggests that members of this conserved family of proteins cooperate in the assembly of SJ components, possibly by promoting core SJ complex formation in intracellular compartments associated with membrane trafficking.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.