ArticleDevelopment (Cambridge, England)2010
Influence of fat-hippo and notch signaling on the proliferation and differentiation of Drosophila optic neuroepithelia.
Article in Development (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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Who cites it
80 citing papers in PubMed, 145 citations in OpenAlex.
- Notch Is Required for Neural Progenitor Proliferation During Embryonic Eye Regrowth.International journal of molecular sciences · 2025Article
- Spatial patterning controls neuron numbers in the Drosophila visual system.Developmental cell · 2024Article
- Article
- A novel proneural function of Asense is integrated with the sequential actions of Delta-Notch, L'sc and Su(H) to promote the neuroepithelial to neuroblast transition.PLoS genetics · 2023Article
- Hippo pathway and Bonus control developmental cell fate decisions in the Drosophila eye.Developmental cell · 2023Article
- Review
- Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain.Nature communications · 2021Article
- Hippo Signaling Pathway in Gliomas.Cells · 2021Review
- Tissue-wide coordination of epithelium-to-neural stem cell transition in the Drosophila optic lobe requires Neuralized.The Journal of cell biology · 2020Article
- A continuation method for spatially discretized models with nonlocal interactions conserving size and shape of cells and lattices.Journal of mathematical biology · 2020Article
- Recent Advances of the Hippo/YAP Signaling Pathway in Brain Development and Glioma.Cellular and molecular neurobiology · 2020Review
- Tep1 Regulates Yki Activity in Neural Stem Cells inFrontiers in cell and developmental biology · 2020Article
- Gene regulatory networks during the development of the Drosophila visual system.Current topics in developmental biology · 2020Review
- Article
- Article
- Hippo signalling during development.Development (Cambridge, England) · 2019Review
- Notch-1 inhibition reduces proliferation and promotes osteogenic differentiation of bone marrow mesenchymal stem cells.Experimental and therapeutic medicine · 2019Article
- The regulation of cell size and branch complexity in the terminal cells of the Drosophila tracheal system.Developmental biology · 2019Article
- The proneural wave in theeLife · 2019Article
- Localization of Hippo Signaling Components in Drosophila by Fluorescence and Immunofluorescence.Methods in molecular biology (Clifton, N.J.) · 2019Article
20 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
The Drosophila optic lobe develops from neuroepithelial cells, which function as symmetrically dividing neural progenitors. We describe here a role for the Fat-Hippo pathway in controlling the growth and differentiation of Drosophila optic neuroepithelia. Mutation of tumor suppressor genes within the pathway, or expression of activated Yorkie, promotes overgrowth of neuroepithelial cells and delays or blocks their differentiation; mutation of yorkie inhibits growth and accelerates differentiation. Neuroblasts and other neural cells, by contrast, appear unaffected by Yorkie activation. Neuroepithelial cells undergo a cell cycle arrest before converting to neuroblasts; this cell cycle arrest is regulated by Fat-Hippo signaling. Combinations of cell cycle regulators, including E2f1 and CyclinD, delay neuroepithelial differentiation, and Fat-Hippo signaling delays differentiation in part through E2f1. We also characterize roles for Jak-Stat and Notch signaling. Our studies establish that the progression of neuroepithelial cells to neuroblasts is regulated by Notch signaling, and suggest a model in which Fat-Hippo and Jak-Stat signaling influence differentiation by their acceleration of cell cycle progression and consequent impairment of Delta accumulation, thereby modulating Notch signaling. This characterization of Fat-Hippo signaling in neuroepithelial growth and differentiation also provides insights into the potential roles of Yes-associated protein in vertebrate neural development and medullablastoma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.