ReviewDevelopment (Cambridge, England)2010
Modeling bistable cell-fate choices in the Drosophila eye: qualitative and quantitative perspectives.
Review in Development (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Pharmacometric modeling with the zero-order hold.Journal of pharmacokinetics and pharmacodynamics · 2025Article
- From genes to patterns: five key dynamical systems concepts to decode developmental regulatory mechanisms.Development (Cambridge, England) · 2025Review
- Deep conservation complemented by novelty and innovation in the insect eye ground plan.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- EnhancerNet: a predictive model of cell identity dynamics through enhancer selection.Development (Cambridge, England) · 2024Article
- Evolution of hierarchy and irreversibility in theoretical cell differentiation model.PNAS nexus · 2024Article
- A bistable autoregulatory module in the developing embryo commits cells to binary expression fates.Current biology : CB · 2023Article
- Origin, heterogeneity, and interconversion of noncanonical bistable switches from the positive feedback loops under dual signaling.iScience · 2023Article
- Ratiometric sensing of Pnt and Yan transcription factor levels confers ultrasensitivity to photoreceptor fate transitions in Drosophila.Development (Cambridge, England) · 2023Article
- Emergent dynamics of a three-node regulatory network explain phenotypic switching and heterogeneity: a case study of Th1/Th2/Th17 cell differentiation.Molecular biology of the cell · 2022Article
- Multiple molecular events underlie stochastic switching between 2 heritable cell states in fungi.PLoS biology · 2022Article
- EyeVolve, a modular PYTHON based model for simulating developmental eye type diversification.Frontiers in cell and developmental biology · 2022Article
- Volumetric compression develops noise-driven single-cell heterogeneity.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A modular approach for modeling the cell cycle based on functional response curves.PLoS computational biology · 2021Article
- A systematic search for switch-like behavior in type II toxin-antitoxin systems.Journal of mathematical biology · 2021Article
- Precision of tissue patterning is controlled by dynamical properties of gene regulatory networks.Development (Cambridge, England) · 2021Article
- Article
- The proneural wave in theeLife · 2019Article
- Notch signalling patterns retinal composition by regulatingDevelopment (Cambridge, England) · 2018Article
- Transcription factor Etv6 regulates functional differentiation of cross-presenting classical dendritic cells.The Journal of experimental medicine · 2018Article
- Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling.PLoS genetics · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major goal of developmental biology is to understand the molecular mechanisms whereby genetic signaling networks establish and maintain distinct cell types within multicellular organisms. Here, we review cell-fate decisions in the developing eye of Drosophila melanogaster and the experimental results that have revealed the topology of the underlying signaling circuitries. We then propose that switch-like network motifs based on positive feedback play a central role in cell-fate choice, and discuss how mathematical modeling can be used to understand and predict the bistable or multistable behavior of such networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.