ReviewDevelopment (Cambridge, England)2010
Modelling the Bicoid gradient.
Review in Development (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
67 citing papers in PubMed.
- Dynamics of bicoid mRNA localisation and translation dictate morphogen gradient formation.The EMBO journal · 2026Article
- Scale invariance in early embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Long-range formation of the Bicoid gradient requires multiple dynamic modes that spatially vary across the embryo.Development (Cambridge, England) · 2024Article
- Revisiting bicoid function: complete inactivation reveals an additional fundamental role in Drosophila egg geometry specification.Hereditas · 2024Article
- Regulation of tissue growth in plants - A mathematical modeling study on shade avoidance response inFrontiers in plant science · 2024Article
- Two-fluid dynamics and micron-thin boundary layers shape cytoplasmic flows in earlyProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Two-fluid dynamics and micron-thin boundary layers shape cytoplasmic flows in earlybioRxiv : the preprint server for biology · 2023Article
- Single-molecule tracking of Nodal and Lefty in live zebrafish embryos supports hindered diffusion model.Nature communications · 2022Article
- How to assemble a scale-invariant gradient.eLife · 2022Article
- Size matters: tissue size as a marker for a transition between reaction-diffusion regimes in spatio-temporal distribution of morphogens.Royal Society open science · 2022Article
- Modulating the bicoid gradient in space and time.Hereditas · 2021Article
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- Mesoderm patterning by a dynamic gradient of retinoic acid signalling.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Quantifying Temperature Compensation of Bicoid Gradients with a Fast T-Tunable Microfluidic Device.Biophysical journal · 2020Article
- DEP-Dots for 3D cell culture: low-cost, high-repeatability, effective 3D cell culture in multiple gel systems.Scientific reports · 2020Article
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- Optogenetic dissection of Rac1 and Cdc42 gradient shaping.Nature communications · 2018Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Morphogen gradients provide embryonic tissues with positional information by inducing target genes at different concentration thresholds and thus at different positions. The Bicoid morphogen gradient in Drosophila melanogaster embryos has recently been analysed quantitatively, yet how it forms remains a matter of controversy. Several biophysical models that rely on production, diffusion and degradation have been formulated to account for the observed dynamics of the Bicoid gradient, but no one model can account for all its characteristics. Here, we discuss how existing data on this gradient fit the various proposed models and what aspects of gradient formation these models fail to explain. We suggest that knowing a few additional parameters, such as the lifetime of Bicoid, would help to identify and develop better models of Bicoid gradient formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.