Evidence map›Paper›PMID 20570731›Full record

ReviewMethods (San Diego, Calif.)2010

What lessons can be learned from studying the folding of homologous proteins?

Adrian A Nickson, Jane Clarke

Open access · hybridAbstract readReview
In one paragraph

Review in Methods (San Diego, Calif.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Review
  3. Folding and Evolution of a Repeat Protein on the Ribosome.Frontiers in molecular biosciences · 2022
    Article
  4. Article
  5. Review
  6. Article
  7. Size and topology modulate the effects of frustration in protein folding.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Unveiling the folding mechanism of the Bromodomains.Biochemistry and biophysics reports · 2017
    Article
  13. Article
  14. Article
  15. Even with nonnative interactions, the updated folding transition states of the homologs Proteins G & L are extensive and similar.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
  16. Protein unfolding rates correlate as strongly as folding rates with native structure.Protein science : a publication of the Protein Society · 2015
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Adrian A NicksonUniversity of Cambridge, Department of Chemistry, MRC Centre for Protein Engineering, Lensfield Road, Cambridge CB2 1EW, UK.
Jane Clarke
University of Cambridge · GB

Funding

Wellcome Trust 064417
6 · The paper itself

Abstract

The studies of the folding of structurally related proteins have proved to be a very important tool for investigating protein folding. Here we review some of the insights that have been gained from such studies. Our highlighted studies show just how such an investigation should be designed and emphasise the importance of the synergy between experiment and theory. We also stress the importance of choosing the right system carefully, exploiting the excellent structural and sequence databases at our disposal.

Indexed as

Protein FoldingAmino Acid SequenceHomeodomain ProteinsKineticsModels, MolecularMolecular Dynamics SimulationProteinsProtein Structure, SecondaryProto-Oncogene Proteins c-mybSequence HomologyThermodynamicsTranscription Factorsengrailed homeobox proteinsHomeodomain ProteinsProteinsProto-Oncogene Proteins c-mybTranscription Factors

Identifiers

PMID20570731
PMCPMC2965948
OpenAlexW1988671180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.