ReviewJournal of insect physiology2010
Engineering the genomes of wild insect populations: challenges, and opportunities provided by synthetic Medea selfish genetic elements.
Review in Journal of insect physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 60 citations in OpenAlex.
- Parental-effect gene-drive elements under partial selfing, or why do Caenorhabditis genomes have hyperdivergent regions?Genetics · 2025Article
- Parental-effect gene-drive elements under partial selfing, or why dobioRxiv : the preprint server for biology · 2024Article
- Adequacy and sufficiency evaluation of existing EFSA guidelines for the molecular characterisation, environmental risk assessment and post-market environmental monitoring of genetically modified insects containing engineered gene drives.EFSA journal. European Food Safety Authority · 2020Article
- Gene drive and resilience through renewal with next generationProceedings of the National Academy of Sciences of the United States of America · 2020Article
- The impact of local population genetic background on the spread of the selfish elementEcology and evolution · 2020Article
- The distribution and spread of naturally occurringEcology and evolution · 2019Article
- Evolutionary simulations ofProceedings. Biological sciences · 2019Article
- Gene drives in plants: opportunities and challenges for weed control and engineered resilience.Proceedings. Biological sciences · 2019Article
- Cleave and Rescue, a novel selfish genetic element and general strategy for gene drive.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Functional analysis of the promoter of an early zygotic gene KLC2 in Aedes aegypti.Parasites & vectors · 2018Article
- Gene editing technologies and applications for insects.Current opinion in insect science · 2018Review
- Recommendations for Laboratory Containment and Management of Gene Drive Systems in Arthropods.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2018Article
- Conditions for success of engineered underdominance gene drive systems.Journal of theoretical biology · 2017Article
- Cheating evolution: engineering gene drives to manipulate the fate of wild populations.Nature reviews. Genetics · 2016Review
- Evidence for temporal population replacement and the signature of ecological adaptation in a major Neotropical malaria vector in Amazonian Peru.Malaria journal · 2015Article
- Disruption of dengue virus transmission by mosquitoes.Current opinion in insect science · 2015Article
- Antipathogen genes and the replacement of disease-vectoring mosquito populations: a model-based evaluation.Evolutionary applications · 2014Article
- Dynamics of a combined Medea-underdominant population transformation system.BMC evolutionary biology · 2014Article
- Novel Genetic and Molecular Tools for the Investigation and Control of Dengue Virus Transmission by Mosquitoes.Current tropical medicine reports · 2014Article
- Identification of germline transcriptional regulatory elements in Aedes aegypti.Scientific reports · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Advances in insect transgenesis and our knowledge of insect physiology and genomics are making it possible to create transgenic populations of beneficial or pest insects that express novel traits. There are contexts in which we may want the transgenes responsible for these traits to spread so that all individuals within a wild population carry them, a process known as population replacement. Transgenes of interest are unlikely to confer an overall fitness benefit on those who carry them. Therefore, an essential component of any population replacement strategy is the presence of a drive mechanism that will ensure the spread of linked transgenes. We discuss contexts in which population replacement might be desirable and the requirements a drive system must satisfy to be both effective and safe. We then describe the creation of synthetic Medea elements, the first selfish genetic elements synthesized de novo, with the capability of driving population replacement, in this case in Drosophila. The strategy used to create Drosophila Medea is applicable to a number of other insect species and the Medea system satisfies key requirements for scientific and social acceptance. Finally, we highlight several challenges to implementing population replacement in the wild.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.