ArticleBrain research2010
Otolith stimulation induces c-Fos expression in vestibular and precerebellar nuclei in cats and squirrel monkeys.
Article in Brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Evaluation of the vestibulo-ocular reflex in head-tilt mutant mice.Biochemistry and biophysics reports · 2025Article
- Widespread neuronal activity related to bimanual coordination in non-human primates: evidence from Fos-like activation during bimanual versus unimanual motor task.Neuroscience insights · 2025Article
- Plastic Events of the Vestibular Nucleus: the Initiation of Central Vestibular Compensation.Molecular neurobiology · 2024Review
- Sensorineural correlates of failed functional recovery after natural regeneration of vestibular hair cells in adult mice.Frontiers in neurology · 2024Article
- Glycine is a transmitter in the human and chimpanzee cochlear nuclei.Frontiers in neuroanatomy · 2024Article
- Behavioral and neural responses to high-strength magnetic fields are reduced in otolith mutant mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Stroboscopic lighting with intensity synchronized to rotation velocity alleviates motion sickness gastrointestinal symptoms and motor disorders in rats.Frontiers in integrative neuroscience · 2022Article
- Species Differences in the Organization of the Ventral Cochlear Nucleus.Anatomical record (Hoboken, N.J. : 2007) · 2018Article
- Head-Eye Vestibular Motion Therapy Affects the Mental and Physical Health of Severe Chronic Postconcussion Patients.Frontiers in neurology · 2017Article
- Glutamate and GABA in Vestibulo-Sympathetic Pathway Neurons.Frontiers in neuroanatomy · 2016Article
- Laminar and neurochemical organization of the dorsal cochlear nucleus of the human, monkey, cat, and rodents.Anatomical record (Hoboken, N.J. : 2007) · 2014Article
- Projection neurons of the vestibulo-sympathetic reflex pathway.The Journal of comparative neurology · 2014Article
- Article
- Fos expression in neurons of the rat vestibulo-autonomic pathway activated by sinusoidal galvanic vestibular stimulation.Frontiers in neurology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Vestibular information is critical for the control of balance, posture, and eye movements. Signals from the receptors, the semicircular canals and otoliths, are carried by the eighth nerve and distributed to the four nuclei of the vestibular nuclear complex, the VNC. However, anatomical and physiological data suggest that many additional brainstem nuclei are engaged in the processing of vestibular signals and generation of motor responses. To assess the role of these structures in vestibular functions, we have used the expression of the immediate early gene c-Fos as a marker for neurons activated by stimulation of the otoliths or the semicircular canals. Excitation of the otolith organs resulted in widespread c-Fos expression in the VNC, but also in other nuclei, including the external cuneate nucleus, the postpyramidal nucleus of the raphé, the nucleus prepositus hypoglossi, the subtrigeminal nucleus, the pontine nuclei, the dorsal tegmental nucleus, the locus coeruleus, and the reticular formation. Rotations that excited the semicircular canals were much less effective in inducing c-Fos expression. The large number of brainstem nuclei that showed c-Fos expression may reflect the multiple functions of the vestibular system. Some of these neurons may be involved in sensory processing of the vestibular signals, while others provide input to the vestibulo-ocular, vestibulocollic, and vestibulospinal reflexes or mediate changes in autonomic function. The data show that otolith stimulation engages brainstem structures both within and outside of the VNC, many of which project to the cerebellum.
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