Evidence map›Paper›PMID 20570552›Full record

ReviewCurrent opinion in microbiology2010

Dueling in the lung: how Cryptococcus spores race the host for survival.

Michael R Botts, Christina M Hull

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 97 citations in OpenAlex.

  1. Molecular Epidemiology and Antifungal Susceptibility ofInfection and drug resistance · 2026
    Article
  2. Review
  3. Article
  4. An Optimized In-House Protocol forJournal of fungi (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Article
  7. Unveiling new features of the human pathogenComputational and structural biotechnology journal · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. A trade-off between proliferation and defense in the fungal pathogenbioRxiv : the preprint server for biology · 2024
    Article
  13. Article
  14. Biogenesis, germination, and pathogenesis ofMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Models for Inducing Experimental Cryptococcosis in Mice.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  19. Article
  20. Connecting Cryptococcal Meningitis and Gut Microbiome.International journal of molecular sciences · 2023
    Review

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Michael R BottsDepartment of Biomolecular Chemistry, University of Wisconsin, School of Medicine and Public Health, Madison, WI 53706, USA.
Christina M Hull
University of Wisconsin–Madison · US

Funding

GRADUATE TRAINING IN MOLECULAR BIOSCIENCEST32GM007215 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HULL, CHRISTINA M · 1985 to 2018
$22.5M
Pathogenesis of Cryptococcus SporesR01AI089370 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI HULL, CHRISTINA M · 2010 to 2014
$1.7M
Sexual development in Cryptococcus neoformansR01AI064287 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI HULL, CHRISTINA M · 2005 to 2009
$1.5M
NIAID NIH HHS R01 AI064287NIAID NIH HHS R01 AI089370NIGMS NIH HHS T32 GM007215
6 · The paper itself

Abstract

Many human fungal pathogens infect people when they are inhaled as spores. Despite the serious impact of fungal spores on human health, little is known about their basic properties or how they interact with the host. This is particularly true for Cryptococcus neoformans, a human fungal pathogen that causes more than 600,000 deaths annually. Spores of C. neoformans have not been well characterized previously because of technical challenges in isolating them; however, recent advances in spore isolation have lead to the first direct analyses of spores. Novel insights into the spore-host interaction, specifically how spores interact with alveolar macrophages, have provided a new model of cryptococcosis that could have broad implications for human fungal pathogenesis.

Indexed as

AnimalsCryptococcosisCryptococcus neoformansHost-Parasite InteractionsHumansLungLung Diseases, FungalMacrophages, AlveolarSpores, FungalVirulence

Identifiers

PMID20570552
PMCPMC2920366
OpenAlexW2030574963

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.