ArticleEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology2011
Involvement of dorsal raphe nucleus and dorsal periaqueductal gray 5-HT receptors in the modulation of mouse defensive behaviors.
Article in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 66 citations in OpenAlex.
- Brain Mechanisms Underlying Panic Attack and Panic Disorder.Neuroscience bulletin · 2024Review
- Freud's 1926 conjecture is confirmed: evidence from the dorsal periaqueductal gray in mice that human psychological defense against internal instinctual threat evolved from animal motor defense against external predatory threat.Frontiers in psychology · 2024Review
- The contribution of periaqueductal gray in the regulation of physiological and pathological behaviors.Frontiers in neuroscience · 2024Review
- A pontomesencephalic PACAPergic pathway underlying panic-like behavioral and somatic symptoms in mice.Nature neuroscience · 2024Article
- Orchestration of innate and conditioned defensive actions by the periaqueductal gray.Neuropharmacology · 2023Review
- Defensive and Emotional Behavior Modulation by Serotonin in the Periaqueductal Gray.Cellular and molecular neurobiology · 2023Review
- Anxiolytic effects of Chrysanthemum morifolium Ramat Carbonisata-based carbon dots in mCPP-induced anxiety-like behavior in mice: a nature-inspired approach.Frontiers in molecular biosciences · 2023Article
- Targeting 5-HT as a Potential Treatment for Social Deficits in Autism.Neuroscience bulletin · 2022Article
- Embracing diversity in the 5-HT neuronal system.Nature reviews. Neuroscience · 2019Review
- Corticotropin-Releasing Factor Receptors in the Locus Coeruleus Modulate the Enhancement of Active Coping Behaviors Induced by Chronic Predator Odor Inoculation in Mice.Frontiers in psychology · 2019Article
- Serotonin Deficiency Increases Context-Dependent Fear Learning Through Modulation of Hippocampal Activity.Frontiers in neuroscience · 2019Article
- Serotonin-specific lesions of the dorsal raphe disrupt maternal aggression and caregiving in postpartum rats.Behavioural brain research · 2018Article
- The Deakin/Graeff hypothesis: focus on serotonergic inhibition of panic.Neuroscience and biobehavioral reviews · 2014Review
- Article
- Sex differences in anxiety and emotional behavior.Pflugers Archiv : European journal of physiology · 2013Review
- Efficacy of chronic antidepressant treatments in a new model of extreme anxiety in rats.Depression research and treatment · 2011Article
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Authors and funding
4 authors at 4 institutions in 2 countries.
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Abstract
Previous findings point to the involvement of the dorsal raphe nucleus (DRN) and dorsal periaqueductal gray (dPAG) serotonergic receptors in the mediation of defensive responses that are associated with specific subtypes of anxiety disorders. These studies have mostly been conducted with rats tested in the elevated T-maze, an experimental model of anxiety that was developed to allow the measurement, in the same animal, of two behaviors mentioned: inhibitory avoidance and one-way escape. Such behavioral responses have been respectively related to generalized anxiety disorder (GAD) and panic disorder (PD). In order to assess the generality of these findings, in the current study we investigated the effects of the injection of 5-HT-related drugs into the DRN and dPAG of another rodent species, mouse, on the mouse defense test battery (MDTB), a test of a range of defensive behaviors to an unconditioned threat, a predator. Male CD-1 mice were tested in the MDTB after intra-DRN administration of the 5-HT(1A) receptor antagonist WAY-100635 or after intra-dPAG injection of two serotonergic agonists, the 5-HT(1A) receptor agonist 8-OH-DPAT and the 5-HT(2A/2C) receptor agonist DOI. Intra-DRN injection of WAY-100635 did not change behavioral responses of mice confronted with a rat in the MDTB. In the dPAG, both 8-OH-DPAT and DOI consistently impaired mouse escape behavior assessed in the MDTB. Intra-dPAG infusion of 8-OH-DPAT also decreased measures of mouse risk assessment in the rat exposure test. In conclusion, the current findings are in partial agreement with previous results obtained with rats tested in the elevated T-maze. Although there is a high level of similarity between the behavioral effects obtained in rats (elevated T-maze) and mice (MDTB and RET) with the infusion of 5-HT agonists into the dPAG, the same is not true regarding the effects of blockade of DRN 5-HT(1A) receptors in these rodent species. These data suggest that there may be differences between mice and rats regarding the involvement of the DRN in the mediation of defensive behaviors.
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