Evidence map›Paper›PMID 20569812›Full record

ReviewClinics in perinatology2010

The role of proteomics in the diagnosis of chorioamnionitis and early-onset neonatal sepsis.

Irina A Buhimschi, Catalin S Buhimschi

Open access · greenAbstract readReview
In one paragraph

Review in Clinics in perinatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. S100A8/A9 in Inflammation.Frontiers in immunology · 2018
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Risk assessment in neonatal early onset sepsis.Seminars in perinatology · 2012
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Quality of antenatal care as a risk factor for early onset neonatal infections in Rio de Janeiro, Brazil.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Irina A BuhimschiDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, LLCI 804, New Haven, CT 06520, USA. irina.buhimschi@yale.edu <irina.buhimschi@yale.edu>
Catalin S Buhimschi
Yale University · US

Funding

A PROTEOMICS COMPUTATIONAL APPROACH TO PRETERM DELIVERYR01HD047321 · NICHD · YALE UNIVERSITY · PI BUHIMSCHI, IRINA A · 2004 to 2008
$1.8M
DAMP-RAGE Signaling and Fetal Injury in Inflammation-Induced Preterm BirthR01HD062007 · NICHD · YALE UNIVERSITY · PI BUHIMSCHI, CATALIN SORIN, BUHIMSCHI, IRINA A · 2010 to 2014
$1.5M
NICHD NIH HHS R01 HD 047321NICHD NIH HHS R01 HD047321NICHD NIH HHS R01 HD062007
6 · The paper itself

Abstract

Intrauterine infection is a unique pathologic process that raises the risk for early-onset neonatal sepsis (EONS). By acting synergistically with prematurity, EONS increases the risk for adverse neonatal outcomes, including intraventricular hemorrhage and cerebral palsy. Although several pathways for the pathogenesis of fetal damage have been proposed, the basic molecular mechanisms that modulate these events remain incompletely understood. Discovery of clinically and biologically relevant biomarkers able to reveal key pathogenic pathways and predict pregnancies at risk for antenatal fetal damage is a priority. Proteomics provides a unique opportunity to fill this gap.

Indexed as

BiomarkersChorioamnionitisDefensinsDiagnosis, DifferentialFemaleGlycation End Products, AdvancedHumansImmunity, InnateInfant, NewbornPregnancyPregnancy Complications, InfectiousProteomicsRisk FactorsSepsisSignal TransductionBiomarkersDefensinsGlycation End Products, Advanced

Identifiers

PMID20569812
PMCPMC2891963
OpenAlexW2020744881

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.