ArticlePolish journal of microbiology2010
Analysis of Helicobacter pylori genotypes in Afghani and Iranian isolates.
Article in Polish journal of microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Analysis ofGastroenterology research · 2018Article
- Different distribution of Helicobacter pylori EPIYA- cagA motifs and dupA genes in the upper gastrointestinal diseases and correlation with clinical outcomes in iranian patients.Gastroenterology and hepatology from bed to bench · 2015Article
- The study of the oipA and dupA genes in Helicobacter pylori strains and their relationship with different gastroduodenal diseases.Gastroenterology and hepatology from bed to bench · 2015Article
- Extremely low Helicobacter pylori prevalence in North Sulawesi, Indonesia and identification of a Maori-tribe type strain: a cross sectional study.Gut pathogens · 2014Article
- Association between Helicobacter pylori, cagA, and vacA Status and Clinical Presentation in Iranian Children.Iranian journal of pediatrics · 2013Article
- Diversity of Helicobacter pylori genotypes in Iranian patients with different gastroduodenal disorders.World journal of gastroenterology · 2013Article
- Study of Helicobacter pylori genotype status in saliva, dental plaques, stool and gastric biopsy samples.World journal of gastroenterology · 2012Article
- Helicobacter pylori in Iran: A systematic review on the association of genotypes and gastroduodenal diseases.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2012Article
- Helicobacter pylori homB, but not cagA, is associated with gastric cancer in Iran.Journal of clinical microbiology · 2011Article
- The role of adenotonsillar tissues as a reservoir for Helicobacter pylori and Helicobacter hepaticus.Gastroenterology and hepatology from bed to bench · 2011Article
- Comparison of the virulence markers of Helicobacter pylori and their associated diseases in patients from Pakistan and Afghanistan.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
The geographical variation in Helicobacter pylori genotypes is an observed phenomenon. Cytotoxin associated genes A (cagA) and E (cagE), and vacuolating cytotoxin (vacA) genotypes of H. pylori are associated with peptic ulcer disease (PUD). This study compared the distribution of these genotypes in Iranian and Afghani isolates and their association with clinical outcomes. H. pylori infected patients, as proven by positive culture, were recruited prospectively. A total of 70 patients, 55 Iranian (26 men and 29 women, mean age 48 +/- 18 years) and 15 Afghani immigrants (13 men and 2 women, mean age 34.8 +/- 11 years) living in Tehran, Iran were enrolled in this study. DNA was extracted from isolated H. pylori and polymerase chain reaction was carried out to determine the cagA and cagE status and vacA alleles. The number of gastric cancer, peptic ulcer and gastritis cases was 11, 23 and 36, respectively. The cagA positive isolates were more common in Iranian (67%) than Afghani isolates (60%). cagE was positive in 53% of Afghani compared to 51% of Iranian isolates. The most common vacA s-region genotype was s1; 80% in Afghani and 67% in Iranian. The slml was a frequently observed genotype in Afghani strains (53%) while s1m2 (47%) was more common in strains isolated from Iranian patients. There is a difference in the H. pylori strains between Iranian and Afghani groups, for instance Iranian isolates were similar to European isolates while Afghani isolates were similar to isolates from India. However, there was no significant association between cagA, cagE and vacA genotypes and clinical outcomes in Iranian and Afghani patients.
Indexed as
Identifiers
20568532PMC3126918W2097659877What OpenQuestion holds
Registered trials
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