ArticleMolecular biology reports2011
Identification and analysis of the promoter region of the human DHCR24 gene: involvement of DNA methylation and histone acetylation.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- DHCR24 in cholesterol metabolism and diseases of the nervous system.Lipids in health and disease · 2026Review
- The Systemic Effect of Ischemia Training and Its Impact on Bone Marrow-Derived Monocytes.Cells · 2024Article
- The role of DHCR24 in the pathogenesis of AD: re-cognition of the relationship between cholesterol and AD pathogenesis.Acta neuropathologica communications · 2022Review
- Integrative Transcriptomics and Proteomics Analysis Provide a Deep Insight Into Bovine Viral Diarrhea Virus-Host Interactions During BVDV Infection.Frontiers in immunology · 2022Article
- Differential placental DNA methylation of VEGFA and LEP in small-for-gestational age fetuses with an abnormal cerebroplacental ratio.PloS one · 2019Article
- Epigenome-wide association study of adiposity and future risk of obesity-related diseases.International journal of obesity (2005) · 2018Article
- Early Life Stress and Epigenetics in Late-onset Alzheimer's Dementia: A Systematic Review.Current genomics · 2018Review
- Ultra-high dimensional variable selection with application to normative aging study: DNA methylation and metabolic syndrome.BMC bioinformatics · 2017Article
- Epigenome-wide association study (EWAS) on lipids: the Rotterdam Study.Clinical epigenetics · 2017Article
- Epigenetics of Lipid Phenotypes.Current cardiovascular risk reports · 2016Article
- Histone Acetylation Modifiers in the Pathogenesis of Alzheimer's Disease.Frontiers in cellular neuroscience · 2015Review
- Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis.Journal of lipid research · 2014Article
- Epigenetic regulation of cholesterol homeostasis.Frontiers in genetics · 2014Review
- Desmosterol in brain is elevated because DHCR24 needs REST for Robust Expression but REST is poorly expressed.Developmental neuroscience · 2014Article
- Promoter analysis of the DHCR24 (3β-hydroxysterol Δ(24)-reductase) gene: characterization of SREBP (sterol-regulatory-element-binding protein)-mediated activation.Bioscience reports · 2012Article
- Methylated promoters of genes encoding protocadherins as a new cancer biomarker family.Molecular biology reports · 2012Article
- DHCR24 in Tumor Diagnosis and Treatment: A Comprehensive Review.Technology in cancer research & treatmentReview
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations in the DHCR24 gene, which encodes the cholesterol biosynthesis enzyme 3ß-hydroxysterol-∆24 reductase, result in an autosomal recessive disease called desmosterolosis. Further, reduced expression of DHCR24 is found in the temporal cortex of Alzheimer's disease patients. This suggests that variability in the regulatory regions of DHCR24 may contribute to the development of this neurodegenerative disease. In this work, we functionally characterised the proximal fragment of the human DHCR24 gene, for the first time. We show that the transcription of DHCR24 is initiated from a single CpG-rich promoter that is regulated by DNA methylation in some cell types. An activator sequence was also uncovered in the -1203/-665 bp region by reporter gene assays. Furthermore, sodium butyrate (a well-known HDAC inhibitor) increased DHCR24 expression in SH-SY5Y cells by recruiting acetylated core histones H3 and H4 to the enhancer region, as demonstrated by transient transfection and chromatin immunoprecipitation assays. Understanding the regulation of the DHCR24 gene may lead to alternative therapeutic strategies in at least some Alzheimer's patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.