ArticleAge (Dordrecht, Netherlands)2011
Enhanced protein repair and recycling are not correlated with longevity in 15 vertebrate endotherm species.
Article in Age (Dordrecht, Netherlands), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Proteostasis and ageing: insights from long-lived mutant mice.The Journal of physiology · 2017Review
- Determinants of rodent longevity in the chaperone-protein degradation network.Cell stress & chaperones · 2016Article
- The impact of base excision DNA repair in age-related neurodegenerative diseases.Mutation research · 2015Review
- Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS).Dose-response : a publication of International Hormesis Society · 2014Article
- A midlife crisis for the mitochondrial free radical theory of aging.Longevity & healthspan · 2014Article
- Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts.Antioxidants & redox signaling · 2013Review
- A comparative cellular and molecular biology of longevity database.Age (Dordrecht, Netherlands) · 2013Review
- Testing predictions of the oxidative stress hypothesis of aging using a novel invertebrate model of longevity: the giant clam (Tridacna derasa).The journals of gerontology. Series A, Biological sciences and medical sciences · 2013Article
- Activities of DNA base excision repair enzymes in liver and brain correlate with body mass, but not lifespan.Age (Dordrecht, Netherlands) · 2012Article
- Extreme longevity is associated with increased resistance to oxidative stress in Arctica islandica, the longest-living non-colonial animal.The journals of gerontology. Series A, Biological sciences and medical sciences · 2011Article
- Mitochondrial DNA damage and animal longevity: insights from comparative studies.Journal of aging research · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have shown that longevity is associated with enhanced cellular stress resistance. This observation supports the disposable soma theory of aging, which suggests that the investment made in cellular maintenance will be proportional to selective pressures to extend lifespan. Maintenance of protein homeostasis is a critical component of cellular maintenance and stress resistance. To test the hypothesis that enhanced protein repair and recycling activities underlie longevity, we measured the activities of the 20S/26S proteasome and two protein repair enzymes in liver, heart and brain tissues of 15 different mammalian and avian species with maximum lifespans (MLSP) ranging from 3 to 30 years. The data set included Snell dwarf mice, in which lifespan is increased by ∼50% compared to their normal littermates. None of these activities in any of the three tissues correlated positively with MLSP. In liver, 20S/26S proteasome and thioredoxin reductase (TrxR) activities correlated negatively with body mass. In brain tissue, TrxR was also negatively correlated with body mass. Glutaredoxin (Grx) activity in brain was negatively correlated with MLSP and this correlation remained after residual analysis to remove the effects of body mass, but was lost when the data were analysed using Felsenstein's independent contrasts. Snell dwarf mice had marginally lower 20S proteasome, TrxR and Grx activities than normal controls in brain, but not heart tissue. Thus, increased longevity is not associated with increased protein repair or proteasomal degradation capacities in vertebrate endotherms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.