ArticleMolecular imaging and biology2011
Evidence for an additional metastatic route: in vivo imaging of cancer cells in the primo-vascular system around tumors and organs.
Article in Molecular imaging and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The role of lymphangiogenesis and angiogenesis in tumor metastasis.Cellular oncology (Dordrecht, Netherlands) · 2016Review
- Cellular fibronectin 1 promotes VEGF-C expression, lymphangiogenesis and lymph node metastasis associated with human oral squamous cell carcinoma.Clinical & experimental metastasis · 2015Article
- Hypothesis on the Treatment of Gliomas with Acupuncture at the Primo Node Corresponding toMedical acupuncture · 2015Article
- Fascia and Primo Vascular System.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- Observation of the Primo Vessel Approaching the Axillary Lymph Node with the Fluorescent Dye, DiI.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Preliminary Research of Relationship between Acute Peritonitis and Celiac Primo Vessels.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- 50 years of bong-han theory and 10 years of primo vascular system.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Discovery of endothelium and mesenchymal properties of primo vessels in the mesentery.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Differentiating blood, lymph, and primo vessels by residual time characteristic of fluorescent nanoparticles in a tumor model.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Primo vascular system accompanying a blood vessel from tumor tissue and a method to distinguish it from the blood or the lymph system.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Observation of a long primo vessel in a lymph vessel from the inguinal node of a rabbit.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Nonendocytic delivery of functional engineered nanoparticles into the cytoplasm of live cells using a novel, high-throughput microfluidic device.Nano letters · 2012Article
- Mathematical Distinction in Action Potential between Primo-Vessels and Smooth Muscle.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Intravital imaging of anti-tumor immune response and the tumor microenvironment.Seminars in immunopathology · 2010Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeResearchers have been studying the mechanisms by which metastasis can be prevented via blocking the hematogenous and the lymphatic routes for a long time now. However, metastasis is still the single most challenging obstacle for successful cancer management. In a new twist that may require some retooling of this established approach, we investigated the hypothesis that tumor metastases can occur via an independent fluid-conducting system called the primo-vascular system. PROCEDURES: The dissemination and growth of near-infrared quantum dot (NIR QD)-electroporated cancer cells in metastatic sites were investigated using in vivo multispectral imaging techniques.
resultsOur results show that the NIR QD-labeled cancer cells were able to migrate through not only the blood vascular and lymphatic systems but also the primo-vascular system extending from around the tumor to inside the abdominal cavity. Furthermore, the NIR QD-labeled cancer cells, which had been seeded intraperitoneally, specifically infiltrated the primo-vascular system in the omentum and in the gonadal fat.
conclusionsThese findings strongly suggest that the primo-vascular system may be an additional metastasis route, complementing the lymphatic and hematogenous routes, which facilitate the dissemination and colonization of cancer cells at secondary sites.
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Registered trials
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