ArticleFamilial cancer2010
Screening for large genomic rearrangements of the BRIP1 and CHK1 genes in Finnish breast cancer families.
Article in Familial cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Biomedical association analysis between G2/M checkpoint genes and susceptibility to HIV-1 infection and AIDS progression from a northern chinese MSM population.AIDS research and therapy · 2023Article
- CD138Aging · 2020Article
- Diagnostic yield of a custom-designed multi-gene cancer panel in Irish patients with breast cancer.Irish journal of medical science · 2020Article
- Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis.Nature communications · 2017Article
- G2/M-Phase Checkpoint Adaptation and Micronuclei Formation as Mechanisms That Contribute to Genomic Instability in Human Cells.International journal of molecular sciences · 2017Review
- Mutation status of RAD51C, PALB2 and BRIP1 in 100 Japanese familial breast cancer cases without BRCA1 and BRCA2 mutations.Cancer science · 2017Article
- Genome wide copy number analyses of superficial esophageal squamous cell carcinoma with and without metastasis.Oncotarget · 2017Article
- Roles of Chk1 in cell biology and cancer therapy.International journal of cancer · 2014Review
- Germline mutations in BRIP1 and PALB2 in Jewish high cancer risk families.Familial cancer · 2012Article
- Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics.Trends in molecular medicine · 2011Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In search for susceptibility genes that could explain an additional portion of familial breast cancer clustering in Finland, we set out to evaluate the presence of large genomic rearrangements in two candidate genes, BRIP1 and CHK1. BRIP1 is a BRCA1 associated protein that is mutated in a fraction of familial breast cancer and Fanconi anemia cases. To date, the role of large BRIP1 deletions in breast cancer susceptibility is not well-characterized. CHK1 is a critical maintainer of cell cycle checkpoints and genomic stability, and is also involved in the BRCA1 and FA protein signalling pathways. Although CHK1 is a very important protein for cell cycle and DNA integrity maintenance control, no mutations in this gene has yet been associated with predisposition to cancer. For the present study, blood DNA from affected index persons of 111 Northern Finnish breast cancer families was assessed for possible constitutional exonic deletions or amplifications in the BRIP1 and CHK1 genes by using the multiplex ligation-dependent probe amplification method. Our results showed that exonic deletions or amplifications affecting the BRIP1 and CHK1 genes seem not to contribute to hereditary breast cancer susceptibility in the Finnish population. To our knowledge, this is the first attempt to determine the existence of large CHK1 deletions in familial breast cancer or in any disease with a hereditary background.
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