ArticleJournal of muscle research and cell motility2010
Myostatin knockout mice increase oxidative muscle phenotype as an adaptive response to exercise.
Article in Journal of muscle research and cell motility, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Aging: A struggle for beneficial to overcome negative factors made by muscle and bone.Mechanisms of ageing and development · 2025Review
- Eicosapentaenoic acid (EPA) improves grass carp (Ctenopharyngodon idellus) muscle development and nutritive value by activating the mTOR signaling pathway.Fish physiology and biochemistry · 2024Article
- Antimyostatin Treatment in Health and Disease: The Story of Great Expectations and Limited Success.Cells · 2021Review
- Article
- Expression Levels of Long Non-Coding RNAs Change in Models of Altered Muscle Activity and Muscle Mass.International journal of molecular sciences · 2020Article
- Mito-nuclear interactions modify Drosophila exercise performance.Mitochondrion · 2019Article
- The double-edged sword of endoplasmic reticulum stress in uremic sarcopenia through myogenesis perturbation.Journal of cachexia, sarcopenia and muscle · 2018Article
- SOCE Is Important for Maintaining Sarcoplasmic Calcium Content and Release in Skeletal Muscle Fibers.Biophysical journal · 2017Article
- New function of the myostatin/activin type I receptor (ALK4) as a mediator of muscle atrophy and muscle regeneration.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Investigating mechanisms underpinning the detrimental impact of a high-fat diet in the developing and adult hypermuscular myostatin null mouse.Skeletal muscle · 2015Article
- Blockade of ActRIIB signaling triggers muscle fatigability and metabolic myopathy.Molecular therapy : the journal of the American Society of Gene Therapy · 2014Article
- Skeletal muscle cellularity and glycogen distribution in the hypermuscular Compact mice.European journal of histochemistry : EJH · 2014Article
- Combinatory effects of siRNA-induced myostatin inhibition and exercise on skeletal muscle homeostasis and body composition.Physiological reports · 2014Article
- Myosin heavy chain mRNA isoforms are expressed in two distinct cohorts during C2C12 myogenesis.Journal of muscle research and cell motility · 2012Article
- Expression and function of myostatin in obesity, diabetes, and exercise adaptation.Medicine and science in sports and exercise · 2011Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Myostatin-deficient mice (MSTN (-/-)) display excessive muscle mass and this is associated with a profound loss of oxidative metabolic properties. In this study we analysed the effect of two endurance-based exercise regimes, either a forced high-impact swim training or moderate intensity voluntary wheel running on the adaptive properties of the tibialis anterior and plantaris muscle from MSTN (-/-) mice. MSTN (-/-) and wild type (MSTN (+/+)) animals had comparable performances in the wheel running regime in terms of distance, average speed and time, but MSTN (-/-) mice showed a reduced ability to sustain a high-impact activity via swimming. Swim training elicited muscle specific adaptations on fibre type distribution in MSTN (-/-); the tibialis anterior displaying a partial transformation in contrast to the plantaris which showed no change. Conversely, wheel running induced similar changes in fibre type composition of both muscles, favouring transitions from IIB-to-IIA. Succinate dehydrogenase activity, an indicator of mitochondrial oxidative potential was increased in response to either exercise regime, with wheel running eliciting more robust changes in the MSTN (-/-) muscles. Examination of the cross sectional area of individual fibre types showed genotype-specific responses with MSTN (-/-) mice exhibiting an incapability of fibre enlargement following the wheel running regime, as opposed to MSTN (+/+) mice and a greater susceptibility to muscle fibre area loss following swimming. In conclusion, the muscle fibre hypertrophy, oxidative capacity and glycolytic phenotype of myostatin deficient muscle can be altered with endurance exercise regimes.
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