ReviewPediatric nephrology (Berlin, Germany)2010
Vitamin D deficiency and toxicity in chronic kidney disease: in search of the therapeutic window.
Review in Pediatric nephrology (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 56 citations in OpenAlex.
- Effects of Calcium, Vitamin D, and Hormone Therapy on Cardiovascular Disease Risk Factors in the Women's Health Initiative: A Randomized Controlled Trial.Obstetrics and gynecology · 2017Trial
- Vitamin D supplementation: Biochemical and inflammatory effects in non-pathological Wistar rats.Toxicology reports · 2025Article
- Association Between 25-hydroxyvitamin D Levels and Adverse Pregnancy Outcomes in Systemic Lupus Erythematosus.Arthritis care & research · 2025Article
- Associations Between Prenatal Vitamin D and Placental Gene Expression.The Journal of nutrition · 2024Article
- The Different Shades of Thermogenic Adipose Tissue.Current obesity reports · 2024Review
- Associations Between Prenatal Vitamin D and Placental Gene Expression.bioRxiv : the preprint server for biology · 2024Article
- Metabolic Advantage of 25(OH)DCells · 2022Article
- Differential Effects of 25-Hydroxyvitamin DCells · 2021Article
- Native vs. active vitamin D in children with chronic kidney disease: a cross-over study.Pediatric nephrology (Berlin, Germany) · 2021Article
- Vitamin D ameliorates adipose browning in chronic kidney disease cachexia.Scientific reports · 2020Article
- Cardiovascular risk factors in children on dialysis: an update.Pediatric nephrology (Berlin, Germany) · 2020Review
- Effect of DOTS Treatment on Vitamin D Levels in Pulmonary Tuberculosis.Journal of clinical and diagnostic research : JCDR · 2017Article
- The Safety Evaluation of Salvianolic Acid B and Ginsenoside Rg1 Combination on Mice.International journal of molecular sciences · 2015Article
- Neurologic Complications of Chronic Kidney Disease.Current neurology and neuroscience reports · 2015Review
- Oral active vitamin d treatment and mortality in maintenance hemodialysis patients.Cardiorenal medicine · 2014Article
- New perspectives on vitamin D food fortification based on a modeling of 25(OH)D concentrations.Nutrition journal · 2013Article
- The effect of vitamin D status on risk factors for cardiovascular disease.Nature reviews. Nephrology · 2013Review
- Vitamin D and inflammation.Pediatric nephrology (Berlin, Germany) · 2013Review
- Intracranial calcification in a uremic infant with Wilms' tumor in a solitary kidney.CEN case reports · 2012Article
- Arterial calcification and bone physiology: role of the bone-vascular axis.Nature reviews. Endocrinology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both vitamin D deficiency and vitamin D toxicity are associated with cardiovascular complications in chronic kidney disease (CKD). Clinical and experiment data indicate that the association of vitamin D levels with cardiovascular disease is best illustrated as a biphasic, or U-shaped, curve. Children and adolescents with CKD need vitamin D due to the demands of a growing skeleton, to prevent renal rickets. However, this therapy carries the risk of severe side effects and chronic toxicity. Observational studies show that vitamin D deficiency and toxicity are frequently present in patients with CKD. In view of the importance of cardiovascular complications for the long-term survival of young patients, these findings demand a judicious use of vitamin D preparations. In clinical practice, the therapeutic window is rather small, presenting a therapeutic challenge to avoid both vitamin D deficiency and toxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.