ArticleJournal of cancer research and clinical oncology2011
RIPK1 and CASP7 polymorphism as prognostic markers for survival in patients with colorectal cancer after complete resection.
Article in Journal of cancer research and clinical oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 27 citations in OpenAlex.
- Interaction of polymorphisms in mitotic regulator genes with cigarette smoking and pancreatic cancer risk.Molecular carcinogenesis · 2013Trial
- The cGAS-STING-related signature affects the prognosis of colorectal cancer through its regulation of multiple immune cells.IUBMB life · 2025Article
- RIPK1 polymorphisms and expression levels: impact on genetic susceptibility and clinical outcome of epithelial ovarian cancer.Cancer cell international · 2023Article
- Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death.Nature reviews. Molecular cell biology · 2023Review
- Innate immune inflammatory cell death: PANoptosis and PANoptosomes in host defense and disease.European journal of immunology · 2023Review
- Article
- RIPK1 polymorphisms alter the susceptibility to cervical Cancer among the Uyghur population in China.BMC cancer · 2020Article
- Immune-Related Prognostic Model in Colon Cancer: A Gene Expression-Based Study.Frontiers in genetics · 2020Article
- Molecular docking analysis of HER-2 inhibitor from the ZINC database as anticancer agents.Bioinformation · 2020Article
- Computing interaction probabilities in signaling networks.EURASIP journal on bioinformatics & systems biology · 2015Article
- Survival is associated with genetic variation in inflammatory pathway genes among patients with resected and unresected pancreatic cancer.Annals of surgery · 2013Article
- Prognostic Impact of Polymorphisms in the CASPASE Genes on Survival of Patients with Colorectal Cancer.Cancer research and treatment · 2012Article
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11 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSince apoptosis plays a key role in cancer progression, the present study analyzed the polymorphisms of apoptosis-related genes and their impact on survival after curative resection in patients with colorectal cancer. MATERIALS AND
methodsThree hundred and seventy-seven patients were enrolled in the present study. The genomic DNA was extracted from fresh colorectal mucosal tissue, and 15 SNPs of 12 apoptosis-related genes were determined using a Sequenom MassARRAY system.
resultsDuring the median follow-up of 41.8 (range, 1.1-85.5) months patients alive at last follow-up, 65 relapses and 57 deaths occurred. Among the target polymorphisms, the RIPK1 rs2272990 in a dominant model and the CASP7 rs2227310 in a recessive model of the minor allele were associated with survival in a log-rank test. Moreover, the GA+AA genotype of the RIPK1 rs2272990 and the GG genotype of the CASP7 rs2227310 were significantly correlated with a worse disease-free (hazard ratio [HR] = 2.093; P = 0.007 and HR = 2.641; 0.002, respectively) and disease-specific survival (HR = 2.222; P = 0.013 and HR = 2.247; P = 0.031, respectively) in a multivariate survival analysis.
conclusionThe RIPK1 and CASP7 polymorphisms can be considered as possible prognostic markers for survival after curative resection in patients with colorectal cancer.
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