ArticlePloS one2010
Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- A Conserved Mechanism of Cardiac Hypertrophy Regression through FoxO1.bioRxiv : the preprint server for biology · 2024Article
- Review
- Administration of alpha klotho reduces liver and adipose lipid accumulation in obese mice.Heliyon · 2019Article
- A mechanistic pan-cancer pathway model informed by multi-omics data interprets stochastic cell fate responses to drugs and mitogens.PLoS computational biology · 2018Article
- FOXO3 and Exceptional Longevity: Insights From Hydra to Humans.Current topics in developmental biology · 2018Article
- A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells.PloS one · 2018Article
- Systems modelling ageing: from single senescent cells to simple multi-cellular models.Essays in biochemistry · 2017Review
- Modelling the molecular mechanisms of aging.Bioscience reports · 2017Review
- Benzylglucosinolate Derived Isothiocyanate from Tropaeolum majus Reduces Gluconeogenic Gene and Protein Expression in Human Cells.PloS one · 2016Article
- A load of mice to hypergravity causes AMPKα repression with liver injury, which is overcome by preconditioning loads via Nrf2.Scientific reports · 2015Article
- Mathematical modeling reveals modulation of both nuclear influx and efflux of Foxo1 by the IGF-I/PI3K/Akt pathway in skeletal muscle fibers.American journal of physiology. Cell physiology · 2014Article
- High fat diet induced obesity alters ovarian phosphatidylinositol-3 kinase signaling gene expression.Reproductive toxicology (Elmsford, N.Y.) · 2013Article
- Forkhead box proteins: tuning forks for transcriptional harmony.Nature reviews. Cancer · 2013Review
- Computational modelling of the regulation of Insulin signalling by oxidative stress.BMC systems biology · 2013Article
- A molecular analysis of desiccation tolerance mechanisms in the anhydrobiotic nematode Panagrolaimus superbus using expressed sequenced tags.BMC research notes · 2012Article
- Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageing.PloS one · 2012Article
- Computational identification and modeling of crosstalk between phosphorylation, O-β-glycosylation and methylation of FoxO3 and implications for cancer therapeutics.International journal of molecular sciences · 2012Article
- Guidelines for visualizing and annotating rule-based models.Molecular bioSystems · 2011Article
- Systems biology of ageing and longevity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
FOXO transcription factors are an important, conserved family of regulators of cellular processes including metabolism, cell-cycle progression, apoptosis and stress resistance. They are required for the efficacy of several of the genetic interventions that modulate lifespan. FOXO activity is regulated by multiple post-translational modifications (PTMs) that affect its subcellular localization, half-life, DNA binding and transcriptional activity. Here, we show how a mathematical modelling approach can be used to simulate the effects, singly and in combination, of these PTMs. Our model is implemented using the Systems Biology Markup Language (SBML), generated by an ancillary program and simulated in a stochastic framework. The use of the ancillary program to generate the SBML is necessary because the possibility that many regulatory PTMs may be added, each independently of the others, means that a large number of chemically distinct forms of the FOXO molecule must be taken into account, and the program is used to generate them. Although the model does not yet include detailed representations of events upstream and downstream of FOXO, we show how it can qualitatively, and in some cases quantitatively, reproduce the known effects of certain treatments that induce various single and multiple PTMs, and allows for a complex spatiotemporal interplay of effects due to the activation of multiple PTM-inducing treatments. Thus, it provides an important framework to integrate current knowledge about the behaviour of FOXO. The approach should be generally applicable to other proteins experiencing multiple regulations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.