ArticleMolecular psychiatry2011
Genetic risk profiles for depression and anxiety in adult and elderly cohorts.
Article in Molecular psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 9 of them syntheses that pooled it.
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Who cites it
76 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression.Molecular psychiatry · 2021Pooled it
- Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium.Biological psychiatry · 2018Pooled it
- The Gene Encoding Protocadherin 9 (PCDH9), a Novel Risk Factor for Major Depressive Disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Pooled it
- Meta-analysis of genome-wide association studies of anxiety disorders.Molecular psychiatry · 2016Pooled it
- Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies.Psychological medicine · 2016Pooled it
- Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels.Nature communications · 2015Pooled it
- A genome-wide association study of depressive symptoms.Biological psychiatry · 2013Pooled it
- Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder.Translational psychiatry · 2012Pooled it
- Meta-analysis of genome-wide association studies for panic disorder in the Japanese population.Translational psychiatry · 2012Pooled it
- Trial
- A genome-wide association study identified 10 novel genomic loci associated with intrinsic capacity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Independent, Multiplicative, and Cumulative Effects of Recent Stressful Life Events and Adverse Childhood Events on Depressive Symptoms among College Students: Moderation by the HPA-axis Multilocus Genetic Variation.Journal of youth and adolescence · 2025Article
- Parental psychiatric disorders and age-specific risk for offspring major depression: Finnish nationwide register-based study.Psychological medicine · 2025Article
- Consumption of sugary beverages, genetic predisposition and the risk of depression: a prospective cohort study.General psychiatry · 2024Article
- Review
- A promising microbial α-amylase production, and purification from Bacillus cereus and its assessment as antibiofilm agent against Pseudomonas aeruginosa pathogen.Microbial cell factories · 2023Article
- Inflammation in the pathogenesis of depression: a disorder of neuroimmune origin.Neuronal signaling · 2023Review
- The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci.Nature computational science · 2023Article
- Factors associated with anxiety disorder comorbidity.Journal of affective disorders · 2023Article
- Association of time spent in outdoor light and genetic risk with the incidence of depression.Translational psychiatry · 2023Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
21 authors.
Funding
Abstract
The first generation of genome-wide association studies (GWA studies) for psychiatric disorders has led to new insights regarding the genetic architecture of these disorders. We now start to realize that a larger number of genes, each with a small contribution, are likely to explain the heritability of psychiatric diseases. The contribution of a large number of genes to complex traits can be analyzed with genome-wide profiling. In a discovery sample, a genetic risk profile for depression was defined based on a GWA study of 1738 adult cases and 1802 controls. The genetic risk scores were tested in two population-based samples of elderly participants. The genetic risk profiles were evaluated for depression and anxiety in the Rotterdam Study cohort and the Erasmus Rucphen Family (ERF) study. The genetic risk scores were significantly associated with different measures of depression and explained up to ∼0.7% of the variance in depression in Rotterdam Study and up to ∼1% in ERF study. The genetic score for depression was also significantly associated with anxiety explaining up to 2.1% in Rotterdam study. These findings suggest the presence of many genetic loci of small effect that influence both depression and anxiety. Remarkably, the predictive value of these profiles was as large in the sample of elderly participants as in the middle-aged samples.
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Registered trials
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