ArticleAJR. American journal of roentgenology2010
A feasibility study of quantitative molecular characterization of musculoskeletal lesions by proton MR spectroscopy at 3 T.
Article in AJR. American journal of roentgenology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 48 citations in OpenAlex.
- Characterization of peripheral nerve sheath tumors with 3T proton MR spectroscopy.AJNR. American journal of neuroradiology · 2014Trial
- Characterization of lipomatous tumors with high-resolutionFrontiers in oncology · 2022Article
- Established paths and new avenues: a review of the main radiological techniques for investigating sarcopenia.Quantitative imaging in medicine and surgery · 2020Review
- Characterisation of musculoskeletal tumours by multivoxel proton MR spectroscopy.Skeletal radiology · 2017Article
- Role of MR spectroscopy in musculoskeletal imaging.The Indian journal of radiology & imaging · 2014Article
- Influence of calcium on choline measurements by 1H MR spectroscopy of thigh muscles.European radiology · 2014Article
- Proton magnetic resonance spectroscopy of skeletal muscle: a comparison of two quantitation techniques.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2014Article
- Schwannoma in neurofibromatosis type 1: a pitfall for detecting malignancy by metabolic imaging.Skeletal radiology · 2013Article
- 3.0 T proton magnetic resonance spectroscopy of the liver: quantification of choline.World journal of gastroenterology · 2013Article
- Musculoskeletal tumors: how to use anatomic, functional, and metabolic MR techniques.Radiology · 2012Review
- Proton MR spectroscopy in metabolic assessment of musculoskeletal lesions.AJR. American journal of roentgenology · 2012Review
- Therapeutic response in musculoskeletal soft tissue sarcomas: evaluation by MRI.NMR in biomedicine · 2011Review
- The year in review: recent advances in musculoskeletal radiology and biology.Skeletal radiology · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe purpose of this study is to establish the feasibility and potential value of measuring the concentration of choline-containing compounds by proton MR spectroscopy (MRS) in musculoskeletal lesions at 3 T. SUBJECTS AND
methodsThirty-three subjects with 34 musculoskeletal lesions (four histologically proven malignant, 13 histologically proven benign or proven benign by follow-up analysis, and 17 posttreatment fibrosis with documented stability for 6-36 months) underwent single-voxel 3-T MRS studies. In each case, both water-suppressed and water-unsuppressed scans were obtained. The quality of the scans was recorded as excellent, adequate, or nondiagnostic, and the choline concentration was measured using water as the internal reference. The choline concentrations of benign and malignant lesions were compared using the Mann-Whitney test.
resultsSpectral quality was excellent in 26 cases, adequate in four cases, and nondiagnostic in four cases. For malignant lesions (three sarcomas), the choline concentrations were 1.5, 2.9, and 3.8 mmol/kg, respectively. For five benign lesions (two neurofibromas, two schwannomas, and one enchondroma), the choline concentrations were 0.11, 0.28, 0.13, 0.8, and 1.2 mmol/kg, respectively. For seven benign lesions (two hematomas, two bone cysts, one lipoma, one giant cell tumor, and one pigmented villonodular synovitis), the spectra showed negligible choline content. For three posttreatment fibrosis cases, the choline concentration range was 0.2-0.4 mmol/kg. For the remaining 12 posttreatment fibrosis cases, the spectra showed negligible choline content. Average choline concentrations were different for malignant and benign lesions (2.7 vs 0.5 mmol/kg; p = 0.01).
conclusionThe measurement of choline concentration within musculoskeletal lesions by MRS is feasible using an internal water-referencing method at 3 T and has potential for characterizing lesions for malignancy.
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