ArticleAntimicrobial agents and chemotherapy2010
Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate.
Article in Antimicrobial agents and chemotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 54 citations in OpenAlex.
- Interaction of the SXT/R391 element ICEMicrobiology spectrum · 2025Article
- Characterization and risk assessment of novel SXT/R391 integrative and conjugative elements with multidrug resistance inMicrobiology spectrum · 2024Article
- Genetic analysis of resistance and virulence characteristics of clinical multidrug-resistantFrontiers in cellular and infection microbiology · 2023Article
- Genomic characteristics of clinical multidrug-resistantFrontiers in microbiology · 2022Article
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- ESBL andFrontiers in microbiology · 2021Article
- Genetics of Acquired Antibiotic Resistance Genes inFrontiers in microbiology · 2020Review
- Genomic Analysis of SXT/R391 Integrative Conjugative Elements FromFrontiers in microbiology · 2020Article
- Targeting Plasmids to Limit Acquisition and Transmission of Antimicrobial Resistance.Frontiers in microbiology · 2020Review
- Article
- Article
- ISFrontiers in microbiology · 2019Article
- Characterization of a Novel SXT/R391 Integrative and Conjugative Element CarryingAntimicrobial agents and chemotherapy · 2018Article
- Redefinition and Unification of the SXT/R391 Family of Integrative and Conjugative Elements.Applied and environmental microbiology · 2018Article
- Pathogenesis ofEcoSal Plus · 2018Review
- ISInfection and drug resistance · 2018Article
- Detection of SGI1/PGI1 Elements and Resistance to Extended-Spectrum Cephalosporins inFrontiers in microbiology · 2017Article
- SXT/R391 integrative and conjugative elements in Proteus species reveal abundant genetic diversity and multidrug resistance.Scientific reports · 2016Article
- High Prevalence of SXT/R391-Related Integrative and Conjugative Elements Carrying blaCMY-2 in Proteus mirabilis Isolates from Gulls in the South of France.Antimicrobial agents and chemotherapy · 2016Article
- Characterization of SXT/R391 Integrative and Conjugative Elements in Proteus mirabilis Isolates from Food-Producing Animals in China.Antimicrobial agents and chemotherapy · 2016Article
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Integrating conjugative elements (ICEs) are mobile genetic elements that can transfer from the chromosome of a host to the chromosome of a new host through the process of excision, conjugation, and integration. Although SXT/R391-related ICEs, originally demonstrated in Vibrio cholerae O139 isolates, have become prevalent among V. cholerae isolates in Asia, the prevalence of the ICEs among gram-negative bacteria other than Vibrio spp. remains unknown. In addition, SXT/R391-related ICEs carrying genes conferring resistance to extended-spectrum cephalosporins have never been described. Here we carried out a genetic analysis of a cefoxitin-resistant Proteus mirabilis clinical isolate, TUM4660, which revealed the presence of a novel SXT/R391-related ICE, ICEPmiJpn1. ICEPmiJpn1 had a core genetic structure showing high similarity to that of R391 and carried xis and int genes completely identical to those of R391, while an IS10-mediated composite transposon carrying bla(CMY-2) was integrated into the ICE. A nucleotide sequence identical to the 3' part of ISEcp1 was located upstream of the bla(CMY-2) gene, and other genes observed around bla(CMY-2) in earlier studies were also present. Furthermore, the nucleotide sequences of hot spot 2 and hot spot 4 in ICEPmiJpn1 showed high similarity to that of hot spot 2 in SXT(MO10) and with a part of the nucleotide sequence found in P. mirabilis ATCC 29906, respectively. ICEPmiJpn1 was successfully transferred to Escherichia coli, Klebsiella pneumoniae, Salmonella enterica serovar Typhimurium, and Citrobacter koseri in conjugation experiments. These observations suggest that ICEs may contribute to the dissemination of antimicrobial resistance genes among clinically relevant Enterobacteriaceae, which warrants careful observation of the prevalence of ICEs, including SXT/R391-related ICEs.
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