Evidence map›Paper›PMID 20566767›Full record

ArticleAntimicrobial agents and chemotherapy2010

In vitro effect of sulfamethoxazole-trimethoprim against Histoplasma capsulatum var. capsulatum.

Raimunda Sâmia Nogueira Brilhante, Maria Auxiliadora Bezerra Fechine, Rossana de Aguiar Cordeiro, Marcos Fábio Gadelha Rocha, Joyce Fonteles Ribeiro, André Jalles Monteiro, Rita Amanda Chaves de Lima, Jacó Ricarte Lima Mesquita, Zoilo Pires de Camargo, José Júlio Costa Sidrim

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Zinc-metallochaperones ofMicrobiology spectrum · 2025
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  4. Article
  5. Antifungal activity of liriodenine on agents of systemic mycoses, with emphasis on the genusThe journal of venomous animals and toxins including tropical diseases · 2020
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Antifolates inhibit Cryptococcus biofilms and enhance susceptibility of planktonic cells to amphotericin B.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2013
    Article
  13. Article
  14. Article
  15. Antiretroviral drugs saquinavir and ritonavir reduce inhibitory concentration values of itraconazole against Histoplasma capsulatum strains in vitro.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Raimunda Sâmia Nogueira BrilhanteSpecialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Federal University of Ceará, Fortaleza, Ceará, Brazil. brilhante@ufc.br
Maria Auxiliadora Bezerra Fechine
Rossana de Aguiar Cordeiro
Marcos Fábio Gadelha Rocha
Joyce Fonteles Ribeiro
André Jalles Monteiro
Rita Amanda Chaves de Lima
Jacó Ricarte Lima Mesquita
Zoilo Pires de Camargo
José Júlio Costa Sidrim

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated the in vitro effect of sulfamethoxazole-trimethoprim against Histoplasma capsulatum var. capsulatum isolated from HIV-positive patients. The drugs were tested by microdilution testing in accordance with the CLSI guidelines. All of the strains were inhibited by sulfamethoxazole-trimethoprim, with MIC ranges of 0.039 (sulfamethoxazole)/0.0078 (trimethoprim) mg/ml to 0.625/0.125 mg/ml for mycelial forms and 0.0025/0.0005 to 0.02/0.004 mg/ml for yeast-like forms. However, in vivo studies are necessary to evaluate the significance of these results.

Indexed as

Anti-Infective AgentsHistoplasmaMicrobial Sensitivity TestsSulfamethoxazoleTrimethoprimAnti-Infective AgentsSulfamethoxazoleTrimethoprim

Identifiers

PMID20566767
PMCPMC2934947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.