ArticleDiabetes2010
Age-period-cohort analysis of 1990-2003 incidence time trends of childhood diabetes in Italy: the RIDI study.
Article in Diabetes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Variation between countries in the frequency of diabetic ketoacidosis at first presentation of type 1 diabetes in children: a systematic review.Diabetologia · 2012Pooled it
- Transitioning Adolescents and Young Adults with Type 1 Diabetes Mellitus in Italy: A Scoping Review.Children (Basel, Switzerland) · 2026Review
- Continuous improvement of quality of care in pediatric diabetes: the ISPED CARD clinical registry.Acta diabetologica · 2024Article
- Trends in incidence rates of childhood type 1 diabetes mellitus: A retrospective study in Isfahan province, Iran.Journal of diabetes investigation · 2023Article
- A comparative study on the incidence of type 1 diabetes mellitus between children of North African migrants and Italian children in Emilia-Romagna region, Italy.European journal of pediatrics · 2022Article
- Incidence of Type 1 diabetes and factors associated with presence and severity of ketoacidosis at onset in children.Acta bio-medica : Atenei Parmensis · 2022Article
- The Gut Microbiota: Master of Puppets Connecting the Epidemiology of Infectious, Autoimmune, and Metabolic Disease.Frontiers in microbiology · 2022Article
- Incidence and Prevalence of Type 1 Diabetes Mellitus among Korean Children and Adolescents between 2007 and 2017: An Epidemiologic Study Based on a National Database.Diabetes & metabolism journal · 2020Article
- Lifestyle Risk Factors for Type 2 Diabetes Mellitus and National Diabetes Care Systems in European Countries.Nutrients · 2020Article
- Endocrine Disrupting Chemicals and Type 1 Diabetes.International journal of molecular sciences · 2020Review
- Insulin/carbohydrates ratio during the first 6-month therapy with insulin degludec in a paediatric population with type 1 diabetes previously treated with insulin glargine. An observational longitudinal study.Endocrinology, diabetes & metabolism · 2020Article
- Prevalence and incidence of type 1 diabetes in the world: a systematic review and meta-analysis.Health promotion perspectives · 2020Review
- Correlating the global increase in type 1 diabetes incidence across age groups with national economic prosperity: A systematic review.World journal of diabetes · 2019Article
- Switching From Glargine to Degludec: The Effect on Metabolic Control and Safety During 1-Year of Real Clinical Practice in Children and Adolescents With Type 1 Diabetes.Frontiers in endocrinology · 2018Article
- Climates on incidence of childhood type 1 diabetes mellitus in 72 countries.Scientific reports · 2017Article
- Incidence of Type 1 Diabetes among Children and Adolescents in Italy between 2009 and 2013: The Role of a Regional Childhood Diabetes Registry.Journal of diabetes research · 2016Article
- A Multicenter Retrospective Survey regarding Diabetic Ketoacidosis Management in Italian Children with Type 1 Diabetes.Journal of diabetes research · 2016Article
- Organization and regional distribution of centers for the management of children and adolescents with diabetes in Italy.Italian journal of pediatrics · 2015Article
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Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate age-period-cohort effects on the temporal trend of type 1 diabetes in children age 0-14 years in Italian registries. RESEARCH DESIGN AND
methodsThis report is based on 5,180 incident cases in the period 1990-2003 from the Registry for Type 1 Diabetes Mellitus in Italy (RIDI). Multilevel (random intercept) Poisson regression models were used to model the effects of sex, age, calendar time, and birth cohorts on temporal trends, taking into account the registry-level variance component.
resultsThe incidence rate was 12.26 per 100,000 person-years and significantly higher in boys (13.13 [95% CI 12.66-13.62]) than in girls (11.35 [10.90-11.82]). Large geographical variations in incidence within Italy were evident; incidence was highest in Sardinia, intermediate in Central-Southern Italy, and high in Northern Italy, particularly in the Trento Province, where the incidence rate was 18.67 per 100,000 person-years. An increasing temporal trend was evident (2.94% per year [95% CI 2.22-3.67]). With respect to the calendar period 1990-1992, the incidence rates increased linearly by 15, 27, 35, and 40% in the following time periods (P for trend < 0.001). With respect to the 1987-1993 birth cohort, the incidence rate ratio increased approximately linearly from 0.63 (95% CI 0.54-0.73) in the 1975-1981 cohort to 1.38 (1.06-1.80) in the 1999-2003 cohort. The best model, however, included sex, age, and a linear time trend (drift).
conclusionsLarge geographical variations and an increasing temporal trend in diabetes incidence are evident among type 1 diabetic children in Italy. Age-period-cohort analysis shows that the variation over time has a linear component that cannot be ascribed to either the calendar period or the birth cohort.
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