ArticleThe Journal of biological chemistry2010
Somatic nucleus reprogramming is significantly improved by m-carboxycinnamic acid bishydroxamide, a histone deacetylase inhibitor.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Strategies to Improve the Efficiency of Somatic Cell Nuclear Transfer.International journal of molecular sciences · 2022Review
- Improved development of mouse somatic cell nuclear transfer embryos by chlamydocin analogues, class I and IIa histone deacetylase inhibitors†.Biology of reproduction · 2021Article
- Chromatin-modifying drugs and metabolites in cell fate control.Cell proliferation · 2020Review
- Lessons Learned from Somatic Cell Nuclear Transfer.International journal of molecular sciences · 2020Review
- Subcellular Characterization of Porcine Oocytes with Different Glucose-6-phosphate Dehydrogenase Activities.Asian-Australasian journal of animal sciences · 2015Article
- Recombinant Human Bone Morphogenetic Protein 6 Enhances Oocyte Reprogramming Potential and Subsequent Development of the Cloned Yak Embryos.Cellular reprogramming · 2015Article
- Trichostatin A-mediated epigenetic transformation of adult bone marrow-derived mesenchymal stem cells biases the in vitro developmental capability, quality, and pluripotency extent of porcine cloned embryos.BioMed research international · 2015Article
- Cell-free extract from porcine induced pluripotent stem cells can affect porcine somatic cell nuclear reprogramming.The Journal of reproduction and development · 2015Article
- MicroRNA-34c expression in donor cells influences the early development of somatic cell nuclear transfer bovine embryos.Cellular reprogramming · 2014Article
- Effects of histone deacetylase inhibitor oxamflatin on in vitro porcine somatic cell nuclear transfer embryos.Cellular reprogramming · 2014Article
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- Recent advancements in cloning by somatic cell nuclear transfer.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Nuclear reprogramming of sperm and somatic nuclei in eggs and oocytes.Reproductive medicine and biology · 2013Article
- Valproic acid treatment from the 4-cell stage improves Oct4 expression and nuclear distribution of histone H3K27me3 in mouse cloned blastocysts.The Journal of reproduction and development · 2013Article
- Strategies to modulate heritable epigenetic defects in cellular machinery: lessons from nature.Pharmaceuticals (Basel, Switzerland) · 2012Article
- Valproic acid improves the in vitro development competence of bovine somatic cell nuclear transfer embryos.Cellular reprogramming · 2012Article
- Uncoupled embryonic and extra-embryonic tissues compromise blastocyst development after somatic cell nuclear transfer.PloS one · 2012Article
- Oocytes selected using BCB staining enhance nuclear reprogramming and the in vivo development of SCNT embryos in cattle.PloS one · 2012Article
- Histone deacetylase inhibitors in cell pluripotency, differentiation, and reprogramming.Stem cells international · 2012Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Somatic cell nuclear transfer (SCNT) has shown tremendous potential for understanding the mechanisms of reprogramming and creating applications in the realms of agriculture, therapeutics, and regenerative medicine, although the efficiency of reprogramming is still low. Somatic nucleus reprogramming is triggered in the short time after transfer into recipient cytoplasm, and therefore, this period is regarded as a key stage for optimizing SCNT. Here we report that CBHA, a histone deacetylase inhibitor, modifies the acetylation status of somatic nuclei and increases the developmental potential of mouse cloned embryos to reach pre- and post-implantation stages. Furthermore, the cloned embryos treated by CBHA displayed higher efficiency in the derivation of nuclear transfer embryonic stem cell lines by promoting outgrowths. More importantly, CBHA increased blastocyst quality compared with trichostatin A, another prevalent histone deacetylase inhibitor reported previously. Use of CBHA should improve the productivity of SCNT for a variety of research and clinical applications, and comparisons of cells with different levels of pluripotency and treated with CBHA versus trichostatin A will facilitate studies of the mechanisms of reprogramming.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.