ArticleThe Journal of biological chemistry2010
Drosophila SIN3 isoforms interact with distinct proteins and have unique biological functions.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 60 citations in OpenAlex.
- Article
- Hangover regulates gene expression by limiting NSL-mediated H4K16 acetylation.Nucleic acids research · 2025Article
- A proximity labeling approach to identify proteins that associate with synaptonemal complex components inbioRxiv : the preprint server for biology · 2025Article
- Heterochromatin-based silencing of a foreign tandem repeat inbioRxiv : the preprint server for biology · 2025Article
- The histone modification regulator, SIN3, plays a role in the cellular response to changes in glycolytic flux.PloS one · 2025Article
- Analysis of the chromatin landscape and RNA polymerase II binding at SIN3-regulated genes.Biology open · 2023Article
- Proximity labeling reveals a new in vivo network of interactors for the histone demethylase KDM5.Epigenetics & chromatin · 2023Article
- Isoforms of the transcriptional cofactor SIN3 differentially regulate genes necessary for energy metabolism and cell survival.Biochimica et biophysica acta. Molecular cell research · 2022Article
- Three classes of epigenomic regulators converge to hyperactivate the essential maternal gene deadhead within a heterochromatin mini-domain.PLoS genetics · 2022Article
- A Chinese hamster transcription start site atlas that enables targeted editing of CHO cells.NAR genomics and bioinformatics · 2021Article
- Histone deacetylase (Rpd3) regulatesOpen biology · 2020Article
- The Lid/KDM5 histone demethylase complex activates a critical effector of the oocyte-to-zygote transition.PLoS genetics · 2020Article
- Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans.Nucleic acids research · 2019Article
- Article
- Systematic Analysis of SIN3 Histone Modifying Complex Components During Development.Scientific reports · 2018Article
- Same agent, different messages: insight into transcriptional regulation by SIN3 isoforms.Epigenetics & chromatin · 2018Review
- Crawling wounded: molecular genetic insights into wound healing from Drosophila larvae.The International journal of developmental biology · 2018Review
- The Transcriptional Corepressor SIN3 Directly Regulates Genes Involved in Methionine Catabolism and Affects Histone Methylation, Linking Epigenetics and Metabolism.The Journal of biological chemistry · 2017Article
- A Looping-Based Model for Quenching Repression.PLoS computational biology · 2017Article
- Inter-isoform-dependent Regulation of the Drosophila Master Transcriptional Regulator SIN3.The Journal of biological chemistry · 2016Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
The SIN3 corepressor serves as a scaffold for the assembly of histone deacetylase (HDAC) complexes. SIN3 and its associated HDAC have been shown to have critical roles in both development and the regulation of cell cycle progression. Although multiple SIN3 isoforms have been reported in simple to complex eukaryotic organisms, the mechanisms by which such isoforms regulate specific biological processes are still largely uncharacterized. To gain insight into how SIN3 isoform-specific function contributes to the growth and development of a metazoan organism, we have affinity-purified two SIN3 isoform-specific complexes, SIN3 187 and 220, from Drosophila S2 cells and embryos. We have identified a number of proteins common to the complexes, including the HDAC RPD3, as well as orthologs of several proteins known to have roles in regulating cell proliferation in other organisms. We additionally identified factors, including the histone demethylase little imaginal discs and histone-interacting protein p55, that exhibited a preferential interaction with the largest SIN3 isoform. Our experiments indicate that the isoforms are associated with distinct HDAC activity and are recruited to unique and shared sites along polytene chromosome arms. Furthermore, although expression of SIN3 220 can substitute for genetic loss of other isoforms, expression of SIN3 187 does not support Drosophila viability. Together our findings suggest that SIN3 isoforms serve distinct roles in transcriptional regulation by partnering with different histone-modifying enzymes.
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