ArticleJournal of neuroscience methods2010
Development of an apparatus and methodology for conducting functional magnetic resonance imaging (fMRI) with pharmacological stimuli in conscious rhesus monkeys.
Article in Journal of neuroscience methods, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Updated Perspectives on the Neurobiology of Substance Use Disorders Using Neuroimaging.Substance abuse and rehabilitation · 2023Review
- Fentanyl-induced changes in brain activity in awake nonhuman primates at 9.4 Tesla.Brain imaging and behavior · 2022Article
- Effects of ketamine treatment on cocaine-induced reinstatement and disruption of functional connectivity in unanesthetized rhesus monkeys.Psychopharmacology · 2019Article
- Improved methods for MRI-compatible implants in nonhuman primates.Journal of neuroscience methods · 2018Article
- Ketamine and pharmacological imaging: use of functional magnetic resonance imaging to evaluate mechanisms of action.Behavioural pharmacology · 2017Review
- Ketamine-induced changes in connectivity of functional brain networks in awake female nonhuman primates: a translational functional imaging model.Psychopharmacology · 2016Article
- Ketamine-induced brain activation in awake female nonhuman primates: a translational functional imaging model.Psychopharmacology · 2016Article
- Functional connectivity in frontal-striatal brain networks and cocaine self-administration in female rhesus monkeys.Psychopharmacology · 2015Article
- Environmental modulation of drug taking: Nonhuman primate models of cocaine abuse and PET neuroimaging.Neuropharmacology · 2014Review
- Monoamine transporter inhibitors and substrates as treatments for stimulant abuse.Advances in pharmacology (San Diego, Calif.) · 2014Review
- Investigation of cross-species translatability of pharmacological MRI in awake nonhuman primate - a buprenorphine challenge study.PloS one · 2014Article
- The effects of alcohol on the nonhuman primate brain: a network science approach to neuroimaging.Alcoholism, clinical and experimental research · 2013Article
- fMRI in the awake marmoset: somatosensory-evoked responses, functional connectivity, and comparison with propofol anesthesia.NeuroImage · 2013Article
- Serotonin 2A receptors differentially contribute to abuse-related effects of cocaine and cocaine-induced nigrostriatal and mesolimbic dopamine overflow in nonhuman primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- A method for conducting functional MRI studies in alert nonhuman primates: initial results with opioid agonists in male cynomolgus monkeys.Experimental and clinical psychopharmacology · 2013Article
- Neuroimaging and drug taking in primates.Psychopharmacology · 2011Review
- Nonhuman primate positron emission tomography neuroimaging in drug abuse research.The Journal of pharmacology and experimental therapeutics · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Functional magnetic resonance imaging (fMRI) is a technique with significant potential to advance our understanding of multiple brain systems. However, when human subjects undergo fMRI studies they are typically conscious whereas pre-clinical fMRI studies typically utilize anesthesia, which complicates comparisons across studies. Therefore, we have developed an apparatus suitable for imaging conscious rhesus monkeys. In order to minimize subject stress and spatial motion, each subject was acclimated to the necessary procedures over several months. The effectiveness of this process was then evaluated, in fully trained subjects, by quantifying objective physiological measures. These physiological metrics were stable both within and across sessions and did not differ from when these same subjects were immobilized using standard primate handling procedures. Subject motion and blood oxygenation level dependent (BOLD) fMRI measurements were then evaluated by scanning subjects under three different conditions: the absence of stimulation, presentation of a visual stimulus, or administration of intravenous (i.v.) cocaine (0.3mg/kg). Spatial motion differed neither by condition nor along the three principal axes. In addition, maximum translational and rotational motion never exceeded one half of the voxel size (0.75 mm) or 1.5 degrees, respectively. Furthermore, the localization of changes in blood oxygenation closely matched those reported in previous studies using similar stimuli. These findings document the feasibility of fMRI data collection in conscious rhesus monkeys using these procedures and allow for the further study of the neural effects of psychoactive drugs.
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