ArticleReproductive toxicology (Elmsford, N.Y.)2010
Alterations in the developing testis transcriptome following embryonic vinclozolin exposure.
Article in Reproductive toxicology (Elmsford, N.Y.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- The antiandrogenic vinclozolin induces differentiation delay of germ cells and changes in energy metabolism in 3D cultures of fetal ovaries.Scientific reports · 2020Article
- Differential susceptibility to endocrine disruptor-induced epimutagenesis.Environmental epigenetics · 2020Review
- Transgenerational latent early-life associated regulation unites environment and genetics across generations.Epigenomics · 2016Article
- Male Reproductive Disorders and Fertility Trends: Influences of Environment and Genetic Susceptibility.Physiological reviews · 2016Review
- Environmentally Induced Epigenetic Transgenerational Inheritance of Altered SRY Genomic Binding During Gonadal Sex Determination.Environmental epigenetics · 2015Article
- Environmental endocrine disruptors: Effects on the human male reproductive system.Reviews in endocrine & metabolic disorders · 2015Review
- Variable directionality of gene expression changes across generations does not constitute negative evidence of epigenetic inheritance.Environmental epigenetics · 2015Article
- Potential roles of noncoding RNAs in environmental epigenetic transgenerational inheritance.Molecular and cellular endocrinology · 2014Review
- Environmentally induced epigenetic transgenerational inheritance of male infertility.Current opinion in genetics & development · 2014Review
- Environmentally induced epigenetic transgenerational inheritance of phenotype and disease.Molecular and cellular endocrinology · 2012Review
- Article
- Basic helix-loop-helix transcription factor TCF21 is a downstream target of the male sex determining gene SRY.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The current study investigates the direct effects of in utero vinclozolin exposure on the developing F1 generation rat testis transcriptome. Previous studies have demonstrated that exposure to vinclozolin during embryonic gonadal sex determination induces epigenetic modifications of the germ line and transgenerational adult onset disease states. Microarray analyses were performed to compare control and vinclozolin treated testis transcriptomes at embryonic days 13, 14 and 16. A total of 576 differentially expressed genes were identified and the major cellular functions and pathways associated with these altered transcripts were examined. The sets of regulated genes at the different development periods were found to be transiently altered and distinct. Categorization by major known functions of altered genes was performed. Specific cellular process and pathway analyses suggest the involvement of Wnt and calcium signaling, vascular development and epigenetic mechanisms as potential mediators of the direct F1 generation actions of vinclozolin.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.