Evidence map›Paper›PMID 20566194›Full record

ArticleEnvironmental research2010

Prenatal exposure to the major DDT metabolite 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and growth in boys from Mexico.

Lea A Cupul-Uicab, Mauricio Hernández-Avila, Efraín A Terrazas-Medina, Michael L Pennell, Matthew P Longnecker

Open access · greenAbstract read
In one paragraph

Article in Environmental research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 4 pooled it
4.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Prenatal exposure to persistent organic pollutants and childhood obesity: A systematic review and meta-analysis of human studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
    Pooled it
  3. Relationship between Prenatal or Postnatal Exposure to Pesticides and Obesity: A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
  4. Association between Exposure toEnvironmental health perspectives · 2017
    Pooled it
  5. Article
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  7. Review
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  14. Agrochemicals and obesity.Molecular and cellular endocrinology · 2020
    Review
  15. Article
  16. Article
  17. Article
  18. Adipose Tissue as a Site of Toxin Accumulation.Comprehensive Physiology · 2017
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Lea A Cupul-UicabEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 TW Alexander Dr, Research Triangle Park, NC 27709, USA. cupuluicabl@niehs.nih.gov
Mauricio Hernández-Avila
Efraín A Terrazas-Medina
Michael L Pennell
Matthew P Longnecker
National Institute of Environmental Health Sciences · USNational Institutes of Health · USThe Ohio State University · US

Funding

Study of Health Effects of DDT in MexicoZIAES044009 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 2009 to 2017
$312k
Study of Health Effects of DDT in MexicoZ01ES044009 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONGNECKER, MATTHEW P · 2001 to 2008
$95k
Intramural NIH HHS Z01 ES044009Intramural NIH HHS Z99 ES999999NIEHS NIH HHS N01-ES-15467
6 · The paper itself

Abstract

Recent data suggest that prenatal exposure to p,p'-DDE may reduce height and increase body mass index (BMI) in childhood, thus potentially raising the risk of adult health problems. The association between prenatal DDE exposure and growth was evaluated in 788 boys from Chiapas, an area of Mexico where DDT was recently used. The median DDE levels in maternal serum at birth (2002-2003) were 2.7 microg/g lipid. 2633 measurements of height (cm) and weight (kg) were obtained in 2004-2005. The median age of the children during follow-up was 18 months (quartiles 14 and 22 months). Height and body mass index (kg/m(2)) were age-standardized and expressed as standard deviation scores (SDS). Multivariate random-effect models for longitudinal data were fitted and predicted height and BMI SDS were estimated from the adjusted models. Overall, associations between prenatal DDE level and height or BMI SDS at any given age were not observed. For example, the predicted values showed that children with the highest exposure (DDE: >9.00 microg/g) compared to those least exposed (DDE: <3.01 microg/g) grew similarly and they had a BMI SDS similar to the referent group. The results do not support the prior findings of an association of DDE exposure with childhood height or BMI.

Indexed as

Maternal ExposureAdolescentAdultBirth WeightBody HeightBody Mass IndexDDTDichlorodiphenyl DichloroethyleneEnvironmental MonitoringFemaleHumansInfantInfant, NewbornLongitudinal StudiesMaleMexicoDDTDichlorodiphenyl Dichloroethylene

Identifiers

PMID20566194
PMCPMC2935620
OpenAlexW2000469846

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.