ArticleScandinavian journal of trauma, resuscitation and emergency medicine2010
"Metabolic staging" after major trauma - a guide for clinical decision making?
Article in Scandinavian journal of trauma, resuscitation and emergency medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- CNS-Spleen Axis - a Close Interplay in Mediating Inflammatory Responses in Burn Patients and a Key to Novel Burn Therapeutics.Frontiers in immunology · 2021Pooled it
- Prescribed hypocaloric nutrition support for critically-ill adults.The Cochrane database of systematic reviews · 2018Pooled it
- A novel in vitro model of trauma-induced endotheliopathy provides a platform for studying mechanisms of coagulopathy.Blood vessels, thrombosis & hemostasis · 2025Article
- Patients with Severe Trauma Having an Injury Severity Score of 24 and above Develop Nutritional Disorders.Diagnostics (Basel, Switzerland) · 2024Article
- Update on Hypermetabolism in Pediatric Burn Patients.Seminars in plastic surgery · 2024Review
- Enteral Feeding in Patients With Open Abdomen and Negative Pressure Therapy: A Propensity Score Analysis.Journal of abdominal wall surgery : JAWS · 2024Article
- Does Route of Full Feeding Affect Outcome among Ventilated Critically Ill COVID-19 Patients: A Prospective Observational Study.Nutrients · 2021Observational
- Energy expenditure and indirect calorimetry in critical illness and convalescence: current evidence and practical considerations.Journal of intensive care · 2021Review
- Metabolic response to maxillofacial trauma revisited: A retrospective study.Journal of family medicine and primary care · 2019Article
- Acute Inflammation and Metabolism.Inflammation · 2018Review
- Energy Requirements in Critically Ill Patients.Clinical nutrition research · 2018Review
- Hepatic mitochondrial bioenergetics in aged C57BL/6 mice exhibit delayed recovery from severe burn injury.Biochimica et biophysica acta. Molecular basis of disease · 2017Article
- Dysfunctional Natural Killer Cells in the Aftermath of Cancer Surgery.International journal of molecular sciences · 2017Review
- Plasma First Resuscitation Reduces Lactate Acidosis, Enhances Redox Homeostasis, Amino Acid and Purine Catabolism in a Rat Model of Profound Hemorrhagic Shock.Shock (Augusta, Ga.) · 2016Article
- Trauma/hemorrhagic shock instigates aberrant metabolic flux through glycolytic pathways, as revealed by preliminary (13)C-glucose labeling metabolomics.Journal of translational medicine · 2015Article
- Early hemorrhage triggers metabolic responses that build up during prolonged shock.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- The role of high-mobility group box-1 (HMGB-1) in the management of suspected acute appendicitis: useful diagnostic biomarker or just another blind alley?Scandinavian journal of trauma, resuscitation and emergency medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Metabolic changes after major trauma have a complex underlying pathophysiology. The early posttraumatic stress response is associated with a state of hyperinflammation, with increased oxygen consumption and energy expenditure. This hypercatabolic state must be recognized early and mandates an early nutritional management strategy. A proactive concept of early enteral "immunonutrition" in severely injured patients, is aimed at counterbalancing the negative aspects of hyperinflammation and hypercatabolism in order to reduce the risk of late complications, including infections and posttraumatic organ failure. Recently, the concept of "metabolic staging" has been advocated, which takes into account the distinct inflammatory phases and metabolic phenotypes after major trauma, including the "ischemia/reperfusion phenotype", the "leukocytic phenotype", and the "angiogenic phenotype". The potential clinical impact of metabolic staging, and of an appropriately adapted "metabolic control" and nutritional support, remains to be determined.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.