ArticleThe Journal of membrane biology1991
Inactivation kinetics and pharmacology distinguish two calcium currents in mouse pancreatic B-cells.
Article in The Journal of membrane biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Ultrafast multicellular calcium imaging of calcium spikes in mouse beta cells in tissue slices.Acta physiologica (Oxford, England) · 2025Article
- Exploring the Pathophysiology of ATP-Dependent Potassium Channels in Insulin Resistance.International journal of molecular sciences · 2024Review
- Exendin-4 affects calcium signalling predominantly during activation and activity of beta cell networks in acute mouse pancreas tissue slices.Frontiers in endocrinology · 2023Article
- Beta-Cell Ion Channels and Their Role in Regulating Insulin Secretion.Comprehensive Physiology · 2021Review
- Hydrogen sulfide-induced inhibition of L-type Ca2+ channels and insulin secretion in mouse pancreatic beta cells.Diabetologia · 2013Article
- Antidiabetic effects of chitooligosaccharides on pancreatic islet cells in streptozotocin-induced diabetic rats.World journal of gastroenterology · 2007Article
- Article
- Voltage-operated calcium channel heterogeneity in pancreatic beta cells: physiopathological implications.Journal of bioenergetics and biomembranes · 2003Review
- The Ca2+ dynamics of isolated mouse beta-cells and islets: implications for mathematical models.Biophysical journal · 2003Article
- The phantom burster model for pancreatic beta-cells.Biophysical journal · 2000Article
- Dynamical complexity and temporal plasticity in pancreatic beta-cells.Journal of biosciences · 2000Review
- Modulation of the bursting properties of single mouse pancreatic beta-cells by artificial conductances.Biophysical journal · 1999Article
- G protein-dependent inhibition of L-type Ca2+ currents by acetylcholine in mouse pancreatic B-cells.The Journal of physiology · 1997Article
- A single non-L-, non-N-type Ca2+ channel in rat insulin-secreting RINm5F cells.Pflugers Archiv : European journal of physiology · 1996Article
- Block of non-L-, non-N-type Ca2+ channels in rat insulinoma RINm5F cells by omega-agatoxin IVA and omega-conotoxin MVIIC.Pflugers Archiv : European journal of physiology · 1995Article
- Correlations of rates of insulin release from islets and plateau fractions for beta-cells.Bulletin of mathematical biology · 1995Article
- Single-microelectrode voltage clamp measurements of pancreatic beta-cell membrane ionic currents in situ.The Journal of membrane biology · 1995Article
- Inactivation of voltage-dependent calcium current in an insulinoma cell line.European biophysics journal : EBJ · 1994Article
- Diffusion of extracellular K+ can synchronize bursting oscillations in a model islet of Langerhans.Biophysical journal · 1993Article
- Sensitivity to dihydropyridines, omega-conotoxin and noradrenaline reveals multiple high-voltage-activated Ca2+ channels in rat insulinoma and human pancreatic beta-cells.Pflugers Archiv : European journal of physiology · 1993Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Voltage-dependent calcium currents were studied in cultured adult mouse pancreatic B-cells using the whole-cell voltage-clamp technique. When calcium currents were elicited with 10-sec depolarizing command pulses, the time course of inactivation was well fit by the sum of two exponentials. The more rapidly-inactivating component had a time constant of 75 +/- 5 msec at 0 mV and displayed both calcium influx- and voltage-dependent inactivation, while the more slowly-inactivating component had a time constant of 2750 +/- 280 msec at 0 mV and inactivated primarily via voltage. The fast component was subject to greater steady-state inactivation at holding potentials between -100 and -40 mV and activated at a lower voltage threshold. This component was also significantly reduced by nimodipine (0.5 microM) when a holding potential of -100 mV was used, whereas the slow component was unaffected. In contrast, the slow component was greatly increased by replacing external calcium with barium, while the fast component was unchanged. Cadmium (1-10 microM) displayed a voltage-dependent block of calcium currents consistent with a greater effect on the high-threshold, more-slowly inactivating component. Taken together, the data suggest that cultured mouse B-cells, as with other insulin-secreting cells we have studied, possess at least two distinct calcium currents. The physiological significance of two calcium currents having distinct kinetic and steady-state inactivation characteristics for B-cell burst firing and insulin secretion is discussed.
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