ArticleAnalytical chemistry2010
Graphene as a novel matrix for the analysis of small molecules by MALDI-TOF MS.
Article in Analytical chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
- Direct Competitive Kinetic Isotope Effect Measurement Using Quantitative Whole Molecule Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry.Chembiochem : a European journal of chemical biology · 2026Article
- MALDI Matrix: Origins, Innovations, and Frontiers.Chemical reviews · 2026Review
- The Role of MALDI-TOF Mass Spectrometry in Photodynamic Therapy: From Photosensitizer Design to Clinical Applications.Current issues in molecular biology · 2025Review
- Synthesis of Silver Nanoparticles by Chemical Vapor Deposition Method and Its Application in Laser Desorption/Ionization Techniques.Nanomaterials (Basel, Switzerland) · 2025Review
- Insights Into the Pathological Glycosylation Associated With COG6-CDG.Human mutation · 2025Article
- Text Mining and Computational Chemistry Reveal Trends in Applications of Laser Desorption/Ionization Techniques to Small Molecules.Journal of the American Society for Mass Spectrometry · 2024Article
- Applications of MALDI mass spectrometry in forensic science.Analytical and bioanalytical chemistry · 2024Review
- Temporally and spatially resolved molecular profiling in fingerprint analysis using indium vanadate nanosheets-assisted laser desorption ionization mass spectrometry.Journal of nanobiotechnology · 2023Article
- Article
- Effects of High-Quality Carbon Nanowalls Ionization-Assisting Substrates on Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Performance.Nanomaterials (Basel, Switzerland) · 2022Article
- Composite PVK/SLGO As Matrix for MALDI-TOF MS Detection of Small Molecules in Dual-Ion Mode.ACS omega · 2022Article
- Metabolic Molecular Diagnosis of Inflammatory Bowel Disease by Synergistical Promotion of Layered Titania Nanosheets with Graphitized Carbon.Phenomics (Cham, Switzerland) · 2022Article
- Amorphous poly-RSC advances · 2022Article
- Laser Ablation Synthesis in Solution and Nebulization of Silver-109 Nanoparticles for Mass Spectrometry and Mass Spectrometry Imaging.ACS measurement science au · 2022Article
- Article
- Principles and Biomedical Application of Graphene Family Nanomaterials.Advances in experimental medicine and biology · 2022Article
- Fabrication and simulation of a layered ultrahigh thermal conductive material made of self-assembled graphene and polydopamine on a copper substrate.RSC advances · 2021Article
- MALDI Matrices for the Analysis of Low Molecular Weight Compounds: Rational Design, Challenges and Perspectives.Chemistry, an Asian journal · 2021Review
- Graphene Oxide Derivatives and Their Nanohybrid Structures for Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Analysis of Small Molecules.Nanomaterials (Basel, Switzerland) · 2021Review
- Effects of Carbon Nanowalls (CNWs) Substrates on Soft Ionization of Low-Molecular-Weight Organic Compoundsin Surface-Assisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS).Nanomaterials (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Graphene was utilized for the first time as a matrix for the analysis of low molecular weight compounds using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Polar compounds including amino acids, polyamines, anticancer drugs, and nucleosides could be successfully analyzed. Additionally, nonpolar compounds including steroids could be detected with high resolution and sensitivity. Compared with a conventional matrix, graphene exhibited a high desorption/ionization efficiency for nonpolar compounds. The graphene matrix functions as a substrate to trap analytes, and it transfers energy to the analytes upon laser irradiation, which allows for the analytes to be readily desorbed/ionized and interference of intrinsic matrix ions to be eliminated. The use of graphene as a matrix avoided the fragmentation of analytes and provided good reproducibility and a high salt tolerance, underscoring the potential application of graphene as a matrix for MALDI MS analysis of practical samples in complex sample matrixes. We also demonstrated that the use of graphene as an adsorbent for the solid-phase extraction of squalene could improve greatly the detection limit. This work not only opens a new field for applications of graphene, but also offers a new technique for high-speed analysis of low molecular weight compounds in areas such as metabolism research and natural product characterization.
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